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Research progress on the regulation of innate immunity and viral infection by IFN-γ inducible protein 16
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Xiangrong LI1, 2, 3, Ping’an DONG1, 3, 4, Rongqian MO1, 3, 4, Ruofei FENG1, 2, 3
Acta Microbiologica Sinica | 2026, 66(2) : 481 - 494
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Acta Microbiologica Sinica | 2026, 66(2): 481-494
• Review •
Research progress on the regulation of innate immunity and viral infection by IFN-γ inducible protein 16
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Xiangrong LI1, 2, 3, Ping’an DONG1, 3, 4, Rongqian MO1, 3, 4, Ruofei FENG1, 2, 3
Affiliations
  • 1.Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 2.Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 3.Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
  • 4.School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, Gansu, China
Published: 2026-02-04 doi: 10.13343/j.cnki.wsxb.20250365
Outline
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Interferon gamma-inducible protein 16 (IFI16), a pivotal member of the pyrin and hematopoietic expression, interferon-inducible nature, and nuclear localization (HIN) domain-containing protein (PYHIN) family, possesses a unique molecular structure that enables it to recognize diverse nucleic acid molecules within cells. As a key immunoregulatory factor, IFI16 participates in the transduction of innate immune signaling through multiple pathways and plays a significant role in host antiviral defense. This review systematically summarized the molecular characteristics of IFI16 and its regulatory mechanisms in innate immunity and viral infection, aiming to provide a theoretical basis for the development of therapeutic targets and antiviral drugs.

interferon gamma-inducible protein 16  /  DNA sensor  /  innate immunity  /  viral infection
Xiangrong LI, Ping’an DONG, Rongqian MO, Ruofei FENG. Research progress on the regulation of innate immunity and viral infection by IFN-γ inducible protein 16[J]. Acta Microbiologica Sinica, 2026 , 66 (2) : 481 -494 . DOI: 10.13343/j.cnki.wsxb.20250365
Funding
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  • the Fundamental Research Funds for the Central Universities(31920240125-01)
  • the Natural Science Foundation of Gansu Province(25JRRA048)
  • the Innovation Fund for University Teachers in Gansu Province(2025B-033)
  • the National Natural Science Foundation of China(32260037)
Appendix
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Year 2026 volume 66 Issue 2
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194
77
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Article Info
doi: 10.13343/j.cnki.wsxb.20250365
  • Receive Date：2025-05-06
  • Online Date：2026-02-05
  • Published：2026-02-04
Article Data
Affiliations
History
  • Received：2025-05-06
  • Accepted：2025-11-28
Funding
the Fundamental Research Funds for the Central Universities(31920240125-01)
the Natural Science Foundation of Gansu Province(25JRRA048)
the Innovation Fund for University Teachers in Gansu Province(2025B-033)
the National Natural Science Foundation of China(32260037)
Affiliations
    1.Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine, Ministry of Education, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    2.Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    3.Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China
    4.School of Life Sciences and Engineering, Northwest Minzu University, Lanzhou, Gansu, China

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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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