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Research progress in the amelioration of hyperuricemia by gut microbiota
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Chunyuan SHI1, Jiang YUE2, Chenjian LIU1, Xiaoran LI1
Acta Microbiologica Sinica | 2026, 66(2) : 547 - 559
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Acta Microbiologica Sinica | 2026, 66(2): 547-559
• Review •
Research progress in the amelioration of hyperuricemia by gut microbiota
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Chunyuan SHI1, Jiang YUE2, Chenjian LIU1, Xiaoran LI1
Affiliations
  • 1.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
  • 2.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Published: 2026-02-04 doi: 10.13343/j.cnki.wsxb.20250639
Outline
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Hyperuricemia is a pathological phenomenon in which the metabolism of uric acid in the human body is disrupted and blood uric acid levels remain above normal. In recent years, gut microbiota has become a research hotspot for various metabolic diseases, serving as a potential new target for the prevention and treatment of hyperuricemia. This article reviews the metabolic pathways and physiological effects of uric acid in the human body and elucidates the regulatory mechanisms of gut microbiota on hyperuricemia. Such mechanisms include inhibiting uric acid synthesis by the breakdown and internalization of purines, degrading uric acid and promoting uric acid excretion, repairing intestinal barriers, influencing intestinal metabolites, and regulating intestinal immunity. In addition, this article summarizes the potential applications of optimizing dietary structure, taking probiotics and prebiotics, and fecal microbiota transplantation in the treatment of hyperuricemia, providing new ideas and references for the prevention and treatment of hyperuricemia.

gut microbiota  /  hyperuricemia  /  purine metabolism
Chunyuan SHI, Jiang YUE, Chenjian LIU, Xiaoran LI. Research progress in the amelioration of hyperuricemia by gut microbiota[J]. Acta Microbiologica Sinica, 2026 , 66 (2) : 547 -559 . DOI: 10.13343/j.cnki.wsxb.20250639
Funding
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  • the Youth Promotion Program of the Peak Climbing Plan for Discipline Construction of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine—“Challenge and Acceptance” Series Projects(RJTJ25-MS-060)
  • the Basic Research Project of Yunnan Provincial Department of Science and Technology(202401AT070846)
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Year 2026 volume 66 Issue 2
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289
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Article Info
doi: 10.13343/j.cnki.wsxb.20250639
  • Receive Date：2025-08-19
  • Online Date：2026-02-05
  • Published：2026-02-04
Article Data
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History
  • Received：2025-08-19
  • Accepted：2025-10-11
Funding
the Youth Promotion Program of the Peak Climbing Plan for Discipline Construction of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine—“Challenge and Acceptance” Series Projects(RJTJ25-MS-060)
the Basic Research Project of Yunnan Provincial Department of Science and Technology(202401AT070846)
Affiliations
    1.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
    2.Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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