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Global hotspots and trends in gut microbiota and metabolic syndrome research based on Web of Science (2005-2024)
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Huiyao ZHANG1, 2, Hao LI1, 2, Tingting ZHOU2, Wenyu WU2, Guodong HUANG2, Zhengqi HUANG1, 2, Haoying HU3, Xianjun RAO2, Lei CHEN2, Wei WEI1, 2
Acta Microbiologica Sinica | 2026, 66(2) : 926 - 955
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Acta Microbiologica Sinica | 2026, 66(2): 926-955
• Special Section •
Global hotspots and trends in gut microbiota and metabolic syndrome research based on Web of Science (2005-2024)
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Huiyao ZHANG1, 2, Hao LI1, 2, Tingting ZHOU2, Wenyu WU2, Guodong HUANG2, Zhengqi HUANG1, 2, Haoying HU3, Xianjun RAO2, Lei CHEN2, Wei WEI1, 2
Affiliations
  • 1.Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
  • 2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
  • 3.Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
Published: 2026-02-04 doi: 10.13343/j.cnki.wsxb.20250521
Outline
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To systematically analyze the current status and research trends and identify the key research hotspots in the field of gut microbiota and metabolic syndrome (MetS) from 2005 to 2024, thus providing references for future research and intervention strategies. Relevant literature on gut microbiota and MetS was retrieved and screened from the Web of Science Core Collection. Bibliometric tools such as VOSviewer, CiteSpace, and the R package bibliometrix were used to analyze the publication trends, countries and institutions, research themes, and emerging hotspots. A total of 4 210 relevant publications were included. The annual number of publications showed an increasing trend, which was particular rapid after 2010. China and the United States led in publication output, and major research findings were published in journals such as Nutrients, Gut, and Nature. Research hotspots primarily covered the fields of nutrition and diet, biochemistry and molecular biology, and microbiology. Keyword evolution analysis revealed a shift from early descriptive studies on gut microbiota composition to mechanism investigations focusing on dysbiosis-related pathways such as energy metabolism, inflammatory responses, and gut-organ axes. Co-occurrence analysis further indicated that key microbial metabolites (e.g., short-chain fatty acids and bile acids) and microbiota-targeted interventions (e.g., probiotics and fecal microbiota transplantation) had become focal points in recent studies. This bibliometric study comprehensively summarizes the research landscape of gut microbiota and MetS and highlights emerging trends and directions. Given the limitations of conventional therapies in terms of targeting specificity, patient adherence, and long-term safety, microbiota-based interventions offer a promising breakthrough for the prevention and treatment of MetS, providing valuable theoretical support for future precision medicine.

gut microbiota  /  metabolic syndrome  /  bibliometrics  /  visualization analysis
Huiyao ZHANG, Hao LI, Tingting ZHOU, Wenyu WU, Guodong HUANG, Zhengqi HUANG, Haoying HU, Xianjun RAO, Lei CHEN, Wei WEI. Global hotspots and trends in gut microbiota and metabolic syndrome research based on Web of Science (2005-2024)[J]. Acta Microbiologica Sinica, 2026 , 66 (2) : 926 -955 . DOI: 10.13343/j.cnki.wsxb.20250521
Funding
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  • the Independent Research Project of Wangjing Hospital, China Academy of Chinese Medical Sciences(WJYY-ZZXT-2023-14)
  • the National Key Research and Development Program of China(2023YFC3503601)
  • the National Natural Science Foundation of China(82204865)
Appendix
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Year 2026 volume 66 Issue 2
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Article Info
doi: 10.13343/j.cnki.wsxb.20250521
  • Receive Date：2025-07-08
  • Online Date：2026-02-05
  • Published：2026-02-04
Article Data
Affiliations
History
  • Received：2025-07-08
  • Accepted：2025-09-17
Funding
the Independent Research Project of Wangjing Hospital, China Academy of Chinese Medical Sciences(WJYY-ZZXT-2023-14)
the National Key Research and Development Program of China(2023YFC3503601)
the National Natural Science Foundation of China(82204865)
Affiliations
    1.Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
    2.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    3.Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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