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Advances in the interaction mechanisms between gut microbiota and host intestinal stem cells
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Fangshen GUO, Wenrui ZHEN, Yi ZHANG, Yanbo MA, Wang LI
Acta Microbiologica Sinica | 2026, 66(2) : 560 - 577
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Acta Microbiologica Sinica | 2026, 66(2): 560-577
• Review •
Advances in the interaction mechanisms between gut microbiota and host intestinal stem cells
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Fangshen GUO, Wenrui ZHEN, Yi ZHANG, Yanbo MA, Wang LI
Affiliations
  • College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Published: 2026-02-04 doi: 10.13343/j.cnki.wsxb.20250648
Outline
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The gut structure and functional performance rely on the stable type and quantity of gut mucosal epithelial cells, whose stability depends on continuous proliferation, differentiation, and migration of intestinal stem cells (ISCs) located in the crypts. Interactions between gut microbiota and ISCs support the homeostasis of the gut ecosystem. Intestinal epithelial cells (IECs) differentiated from ISCs influence the composition and function of gut microbiota through secreting immunoglobulins, mucins, etc. Meanwhile, the microorganism-associated molecular patterns (such as lipoteichoic acid and lipopolysaccharides) and metabolites (such as short-chain fatty acids and bile acids) from gut microbiota form the unique gut microenvironment to regulate the activity of ISCs and the homeostasis of IECs. Regulating the activity of ISCs and gut health by modifying gut microbiota has become a focus of current research. Thus, this review elaborates on the impact of ISCs on the gut microbiota as well as the regulatory roles of gut microbiota and related metabolites on the proliferation and differentiation fate of ISCs, aiming to broaden the understanding of the interaction between gut microbiota and ISCs. It is expected to provide strategies and targets for the regulation on gut health.

intestinal stem cells  /  gut microbiota  /  microbial metabolites
Fangshen GUO, Wenrui ZHEN, Yi ZHANG, Yanbo MA, Wang LI. Advances in the interaction mechanisms between gut microbiota and host intestinal stem cells[J]. Acta Microbiologica Sinica, 2026 , 66 (2) : 560 -577 . DOI: 10.13343/j.cnki.wsxb.20250648
Funding
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  • the Henan Provincial Natural Science Foundation Youth Program(252300421652)
Appendix
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Year 2026 volume 66 Issue 2
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279
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Article Info
doi: 10.13343/j.cnki.wsxb.20250648
  • Receive Date：2025-08-23
  • Online Date：2026-02-05
  • Published：2026-02-04
Article Data
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History
  • Received：2025-08-23
  • Accepted：2025-10-04
Funding
the Henan Provincial Natural Science Foundation Youth Program(252300421652)
Affiliations
    College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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