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Numb-associated kinases: physiological functions and roles in viral infection
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Rui LI1, Yan JIANG1, Lingqiao YOU1, Yueyin SUN1, Jiahui LI1, Yu’e WANG1, 2, *, Longxiang ZHANG1, *
Acta Microbiologica Sinica | 2026, 66(1) : 149 - 169
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Acta Microbiologica Sinica | 2026, 66(1): 149-169
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Numb-associated kinases: physiological functions and roles in viral infection
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Rui LI1, Yan JIANG1, Lingqiao YOU1, Yueyin SUN1, Jiahui LI1, Yu’e WANG1, 2, *, Longxiang ZHANG1, *
Affiliations
  • 1.College of Veterinary Medicine, Southwest University, Chongqing, China
  • 2.National Center of Technology Innovation for Pigs, Chongqing, China
Published: 2026-01-04 doi: 10.13343/j.cnki.wsxb.20250587
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Numb-associated kinases (NAKs) are a family of evolutionarily conserved serine/threonine kinases, encompassing adaptor-associated kinase 1 (AAK1), cyclin G-associated kinase (GAK), bone morphogenetic protein 2-inducible kinase (BMP2K), and serine/threonine kinase 16 (STK16). NAKs are widely involved in various physiological processes, such as endocytosis, intracellular transport, cell differentiation, autophagy, and signal transduction. In recent years, studies have shown that NAKs play a key role in different life cycle stages including virus entry, assembly, release, and immune escape of various viruses. Furthermore, small-molecule inhibitors targeting NAKs have been applied in clinical research and treatment of related physiological or viral infectious diseases. This article systematically reviews the primary physiological functions of NAKs and their roles in viral infection, aiming to provide a theoretical foundation for elucidating the pathogenic mechanisms of viruses and developing novel therapeutic drugs targeting NAKs.

Numb-associated kinases  /  physiological function  /  small-molecule inhibitors  /  virus life cycle
Rui LI, Yan JIANG, Lingqiao YOU, Yueyin SUN, Jiahui LI, Yu’e WANG, Longxiang ZHANG. Numb-associated kinases: physiological functions and roles in viral infection[J]. Acta Microbiologica Sinica, 2026 , 66 (1) : 149 -169 . DOI: 10.13343/j.cnki.wsxb.20250587
Funding
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  • National Natural Science Foundation of China(32302852)
  • Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0366)
  • Fundamental Research Funds for the Central Universities(SWU-KQ22035)
  • Southwest University Training Program of Innovation and Entrepreneurship for Undergraduates Project(S202510635265)
  • Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300224)
Appendix
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Year 2026 volume 66 Issue 1
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214
82
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Article Info
doi: 10.13343/j.cnki.wsxb.20250587
  • Receive Date：2025-07-29
  • Online Date：2026-01-12
  • Published：2026-01-04
Article Data
Affiliations
History
  • Received：2025-07-29
  • Accepted：2025-09-10
Funding
National Natural Science Foundation of China(32302852)
Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0366)
Fundamental Research Funds for the Central Universities(SWU-KQ22035)
Southwest University Training Program of Innovation and Entrepreneurship for Undergraduates Project(S202510635265)
Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300224)
Affiliations
    1.College of Veterinary Medicine, Southwest University, Chongqing, China
    2.National Center of Technology Innovation for Pigs, Chongqing, China

Corresponding:

*E-mail: ZHANG Longxiang,
WANG Yu’e,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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