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Research progress in the antiviral effects and mechanisms of chloroquine
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Haolin LI, Yu DAI, Rendong FANG, Chao YE*
Acta Microbiologica Sinica | 2026, 66(1) : 92 - 103
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Acta Microbiologica Sinica | 2026, 66(1): 92-103
• Review •
Research progress in the antiviral effects and mechanisms of chloroquine
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Haolin LI, Yu DAI, Rendong FANG, Chao YE*
Affiliations
  • Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China
Published: 2026-01-04 doi: 10.13343/j.cnki.wsxb.20250547
Outline
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Chloroquine, a low-cost antimalarial agent, has garnered significant interest due to its extensive research foundation and potential anti-tumor and antiviral properties. Chloroquine exhibits broad-spectrum inhibitory effects against diverse human and animal pathogenic viruses in vitro. Its antiviral efficacy has been demonstrated against Zika virus and feline coronavirus in vivo. The primary action mechanisms of chloroquine include inhibition of viral binding to host cells and subsequent internalization, modulation of viral nucleic acid recognition pathways, blockade of autophagosome maturation, and regulation of cytokine secretion in the immune response. This review systematically summarizes the antiviral effects and mechanisms of chloroquine, providing a theoretical foundation for the future development of chloroquine and its derivatives as antivirals.

chloroquine  /  viruses  /  mechanisms
Haolin LI, Yu DAI, Rendong FANG, Chao YE. Research progress in the antiviral effects and mechanisms of chloroquine[J]. Acta Microbiologica Sinica, 2026 , 66 (1) : 92 -103 . DOI: 10.13343/j.cnki.wsxb.20250547
Funding
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  • National Natural Science Foundation of China(32372982)
  • National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
  • Chongqing Modern Agricultural Industry Technology System(CQMAITS202512)
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Year 2026 volume 66 Issue 1
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267
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Article Info
doi: 10.13343/j.cnki.wsxb.20250547
  • Receive Date：2025-07-17
  • Online Date：2026-01-12
  • Published：2026-01-04
Article Data
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History
  • Received：2025-07-17
  • Accepted：2025-08-23
Funding
National Natural Science Foundation of China(32372982)
National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
Chongqing Modern Agricultural Industry Technology System(CQMAITS202512)
Affiliations
    Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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