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Recent advancements in the functional forms of the β-barrel assembly machinery in Escherichia coli
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Qing WANG1, Wenyu HAN1, Qingrong LI2, Leyi ZHAO2, Hanqing ZHANG2, Yunli GUO1, Youcai QIN2, Xinxin LIANG1, Enguo FAN1, 2, Yindi CHU2, *
Acta Microbiologica Sinica | 2025, 65(12) : 5244 - 5256
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Acta Microbiologica Sinica | 2025, 65(12): 5244-5256
• Review •
Recent advancements in the functional forms of the β-barrel assembly machinery in Escherichia coli
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Qing WANG1, Wenyu HAN1, Qingrong LI2, Leyi ZHAO2, Hanqing ZHANG2, Yunli GUO1, Youcai QIN2, Xinxin LIANG1, Enguo FAN1, 2, Yindi CHU2, *
Affiliations
  • 1.College of Life Sciences, Linyi University, Linyi, Shandong, China
  • 2.Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
Published: 2025-12-04 doi: 10.13343/j.cnki.wsxb.20250428
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The β-barrel assembly machinery (BAM) complex is an essential apparatus that is responsible for the assembly of β-barrel outer membrane proteins (OMPs) into the outer membrane of Gram-negative bacteria. Its functional defects can lead to bacterial death, and thus it is established as a new target for antibacterial drug development. The subunit composition of the BAM complex varies across different bacterial species and in Escherichia coli, it is composed of a core subunit BamA and auxiliary lipoproteins BamB-E. BamA, as a member of the Omp85 family, mediates the folding and release of substrate OMPs through the dynamic conformational changes of its β-barrel structure that are regulated by lipoproteins. In the present review, we summarized recent progress in distinguishing the minimal functional unit, complete functional unit, and other functional units of the BAM complex in E. coli. Moreover, by reviewing the drug screening studies targeting the BAM complex, we provided an overview of new strategies to combat the drug resistance of Gram-negative bacteria.

BAM complex  /  outer membrane protein  /  functional forms  /  BamADE
Qing WANG, Wenyu HAN, Qingrong LI, Leyi ZHAO, Hanqing ZHANG, Yunli GUO, Youcai QIN, Xinxin LIANG, Enguo FAN, Yindi CHU. Recent advancements in the functional forms of the β-barrel assembly machinery in Escherichia coli[J]. Acta Microbiologica Sinica, 2025 , 65 (12) : 5244 -5256 . DOI: 10.13343/j.cnki.wsxb.20250428
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  • National Natural Science Foundation of China(32200153)
Appendix
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Year 2025 volume 65 Issue 12
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Article Info
doi: 10.13343/j.cnki.wsxb.20250428
  • Receive Date：2025-06-03
  • Online Date：2025-12-08
  • Published：2025-12-04
Article Data
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History
  • Received：2025-06-03
  • Accepted：2025-07-11
Funding
National Natural Science Foundation of China(32200153)
Affiliations
    1.College of Life Sciences, Linyi University, Linyi, Shandong, China
    2.Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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