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Yeast dietary fiber regulates arsenic-induced apoptosis in yeast cells by modulating the antioxidant system
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Lihua WU*, Wenjun GE, Xia YAO, Weiling DONG, Wenjing ZHAO
Acta Microbiologica Sinica | 2025, 65(12) : 5352 - 5361
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Acta Microbiologica Sinica | 2025, 65(12): 5352-5361
• Research Article •
Yeast dietary fiber regulates arsenic-induced apoptosis in yeast cells by modulating the antioxidant system
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Lihua WU*, Wenjun GE, Xia YAO, Weiling DONG, Wenjing ZHAO
Affiliations
  • College of Biological Sciences and Technology, Taiyuan Normal University, Jinzhong, Shanxi, China
Published: 2025-12-04 doi: 10.13343/j.cnki.wsxb.20250367
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Objective To investigate the effect of yeast dietary fiber (YDF) on arsenic-induced apoptosis in Saccharomyces cerevisiae and decipher the possible mechanism. Methods The relative survival rate, apoptosis, and antioxidant indicators were determined by the spread plate method, spectrophotometry, fluorescence microscopy, and RT-qPCR. Results The exposure to arsenic significantly decreased the relative survival rate, elevated the intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and induced apoptosis. However, in the presence of YDF (0.5 mg/mL or 1.0 mg/mL) and arsenic, the arsenic-induced toxic effects were effectively attenuated, which was evidenced by increases in the relative survival rate, content of glutathione, activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and relative expression of antioxidant enzyme genes (SOD1, CTA1, CTT1, and GPX2). Moreover, the treatment with both YDF and arsenic lowered the ROS and the MDA levels, significantly down-regulated the relative expression levels of pro-apoptotic genes (AIF1, NMAⅢ, and NUC1), and significantly reduced apoptotic cells compared with the treatment with arsenic alone. Conclusion YDF regulates the antioxidant system to attenuate the arsenic-induced cytotoxicity, thereby alleviating the arsenic-induced apoptosis.

yeast dietary fiber  /  Saccharomyces cerevisiae  /  sodium arsenite  /  apoptosis  /  antioxidant system
Lihua WU, Wenjun GE, Xia YAO, Weiling DONG, Wenjing ZHAO. Yeast dietary fiber regulates arsenic-induced apoptosis in yeast cells by modulating the antioxidant system[J]. Acta Microbiologica Sinica, 2025 , 65 (12) : 5352 -5361 . DOI: 10.13343/j.cnki.wsxb.20250367
Funding
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  • National Natural Science Foundation of China(21307087)
  • Scientific and Technological Innovation Program of Higher Education Institutions in Shanxi Province(2019L0820)
  • Innovative Training Program for College Students of Shanxi Province(20251297)
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Year 2025 volume 65 Issue 12
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Article Info
doi: 10.13343/j.cnki.wsxb.20250367
  • Receive Date：2025-05-06
  • Online Date：2025-12-08
  • Published：2025-12-04
Article Data
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History
  • Received：2025-05-06
  • Accepted：2025-06-12
Funding
National Natural Science Foundation of China(21307087)
Scientific and Technological Innovation Program of Higher Education Institutions in Shanxi Province(2019L0820)
Innovative Training Program for College Students of Shanxi Province(20251297)
Affiliations
    College of Biological Sciences and Technology, Taiyuan Normal University, Jinzhong, Shanxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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