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From the perspective of the “oral-gut axis”: the role of Peptostreptococcus in colorectal cancer progression
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Yuhong ZHU1, Zhanli GUO1, Xueke LI1, 2, *, Qixuan KUANG1, Xi FU1, 3, Yifang JIANG1, Qiong MA1, Fengming YOU1, 3, Chuan ZHENG1, *
Acta Microbiologica Sinica | 2025, 65(12) : 5209 - 5227
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Acta Microbiologica Sinica | 2025, 65(12): 5209-5227
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From the perspective of the “oral-gut axis”: the role of Peptostreptococcus in colorectal cancer progression
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Yuhong ZHU1, Zhanli GUO1, Xueke LI1, 2, *, Qixuan KUANG1, Xi FU1, 3, Yifang JIANG1, Qiong MA1, Fengming YOU1, 3, Chuan ZHENG1, *
Affiliations
  • 1.TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
  • 2.Department of Oncology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
  • 3.Cancer Institute, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
Published: 2025-12-04 doi: 10.13343/j.cnki.wsxb.20250381
Outline
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Colorectal cancer (CRC), a common malignant neoplasm of the digestive system globally, demonstrates pathological progression that is intricately linked not only to dysbiosis of the gut microbiota but also to the oral microbial ecosystem. The emerging concept of the “oral-gut axis” offers novel insights into the regulation of microbial interactions across different organs. Recent research indicates that Peptostreptococcus, a predominant genus within the oral microbiome, exhibits spatiotemporal correlations with the initiation and progression of CRC. This genus may influence intestinal microecological changes and CRC pathogenesis through the “oral-gut axis”. We explore the microbial interactions between oral and intestinal ecosystems, examining the multidimensional associations between specific Peptostreptococcus species (such as P. stomatis and P. anaerobius) and CRC development. Key considerations include the population heterogeneity of these species among CRC patients with varying clinical profiles, their dynamic evolution during the adenoma-carcinoma sequence, and their spatial distribution across different pathological stages. We synthesize mechanistic evidence illustrating the role of Peptostreptococcus in promoting tumorigenesis by enhancing cancer cell proliferation, inducing epithelial-mesenchymal transition, and remodeling the tumor microenvironment. Additionally, this article assesses the clinical potential of Peptostreptococcus as predictive biomarkers and therapeutic targets for CRC. Finally, we propose future directions for the development of targeted microbial intervention strategies against oral-derived pathogens, with the aim of stimulating scientific interest and encouraging further investigation in this emerging research area.

oral-gut axis  /  colorectal cancer  /  Peptostreptococcus  /  mechanism of action  /  biomarker
Yuhong ZHU, Zhanli GUO, Xueke LI, Qixuan KUANG, Xi FU, Yifang JIANG, Qiong MA, Fengming YOU, Chuan ZHENG. From the perspective of the “oral-gut axis”: the role of Peptostreptococcus in colorectal cancer progression[J]. Acta Microbiologica Sinica, 2025 , 65 (12) : 5209 -5227 . DOI: 10.13343/j.cnki.wsxb.20250381
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  • Natural Science Foundation of Science and Technology Department of Sichuan Province(2024NSFSC1849)
Appendix
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Year 2025 volume 65 Issue 12
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288
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Article Info
doi: 10.13343/j.cnki.wsxb.20250381
  • Receive Date：2025-05-09
  • Online Date：2025-12-08
  • Published：2025-12-04
Article Data
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History
  • Received：2025-05-09
  • Accepted：2025-06-20
Funding
Natural Science Foundation of Science and Technology Department of Sichuan Province(2024NSFSC1849)
Affiliations
    1.TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
    2.Department of Oncology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
    3.Cancer Institute, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

Corresponding:

*E-mail: LI Xueke, ;
ZHENG Chuan,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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