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Baicalin protects mice from infection with porcine extraintestinal pathogenic Escherichia colivia alleviating the inflammatory response
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Wei LIU1, Mingxing REN1, Peiyi WANG1, Yong XIAO1, Aihua WU1, Yanyan ZHANG1, 2, 3, Shulin FU1, 2, 3, Yinsheng QIU1, 2, 3, Bingbing ZONG1, 2, 3, *
Acta Microbiologica Sinica | 2025, 65(11) : 4951 - 4960
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Acta Microbiologica Sinica | 2025, 65(11): 4951-4960
• Research Article •
Baicalin protects mice from infection with porcine extraintestinal pathogenic Escherichia colivia alleviating the inflammatory response
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Wei LIU1, Mingxing REN1, Peiyi WANG1, Yong XIAO1, Aihua WU1, Yanyan ZHANG1, 2, 3, Shulin FU1, 2, 3, Yinsheng QIU1, 2, 3, Bingbing ZONG1, 2, 3, *
Affiliations
  • 1 School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, Hubei, China
  • 2 Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Wuhan, Hubei, China
  • 3 Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Wuhan, Hubei, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250281
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Objective To study the protective effect of baicalin on mice infected by porcine extraintestinal pathogenic Escherichia coli (ExPEC) PCN033 strain and explore the underlying mechanism. Methods The mouse infection model and Western blotting were employed to determine the clinical features, survival rate, bacterial loads in different tissue samples, pathological changes, and expression levels of P65, IκBα, NLRP3, ASC, and Caspase-1 of mice in the infection group and the baicalin treatment group. Results After baicalin treatment, the mental state of mice in the baicalin treatment group was obviously better than that in the infection group. The survival rate of mice in the baicalin treatment group was higher than that in the infection group, and the colonization ability of PCN033 in the blood, brain, and lung of mice in the baicalin treatment group was lower than that in the infection group. Further studies showed that baicalin inhibited the PCN033 infection-induced activation of phosphorylation of P65 and IκBα and down-regulated the expression levels of NLRP3, ASC, and Caspase-1 in mice. Conclusion Baicalin alleviated the inflammatory response caused by porcine ExPEC infection by inhibiting NF-κB signaling pathway and blocking the activation of NLRP3 inflammasome, thereby reducing the clinical symptoms and tissue damage in mice. It is suggested that baicalin may be a potential drug to prevent and treat porcine ExPEC infection by regulating the inflammatory response.

porcine extraintestinal pathogenic Escherichia coli  /  baicalin  /  survival rate  /  bacterial load in tissue  /  inflammatory response
Wei LIU, Mingxing REN, Peiyi WANG, Yong XIAO, Aihua WU, Yanyan ZHANG, Shulin FU, Yinsheng QIU, Bingbing ZONG. Baicalin protects mice from infection with porcine extraintestinal pathogenic Escherichia colivia alleviating the inflammatory response[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4951 -4960 . DOI: 10.13343/j.cnki.wsxb.20250281
Funding
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  • National Natural Science Foundation of China(32202814)
  • Hubei Province Key Research and Development Plan(2023BBB069)
Appendix
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Year 2025 volume 65 Issue 11
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175
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Article Info
doi: 10.13343/j.cnki.wsxb.20250281
  • Receive Date：2025-04-07
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
Affiliations
History
  • Received：2025-04-07
  • Accepted：2025-05-19
Funding
National Natural Science Foundation of China(32202814)
Hubei Province Key Research and Development Plan(2023BBB069)
Affiliations
    1 School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, Hubei, China
    2 Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Wuhan, Hubei, China
    3 Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Wuhan, Hubei, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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