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Research progress in the regulation of host cell apoptosis by intracellular pathogens
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Maoshuang RAN1, 2, Jialing BAO1, 2, Guoqing PAN1, 2, *
Acta Microbiologica Sinica | 2025, 65(11) : 4827 - 4841
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Acta Microbiologica Sinica | 2025, 65(11): 4827-4841
• Review •
Research progress in the regulation of host cell apoptosis by intracellular pathogens
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Maoshuang RAN1, 2, Jialing BAO1, 2, Guoqing PAN1, 2, *
Affiliations
  • 1 State Key Laboratory of Resource Insects, Southwest University, Chongqing, China
  • 2 Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250357
Outline
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In multicellular organisms, cell death is perpetually in a dynamic process. Apoptosis as a pivotal form of regulated cell death, mainly encompasses two pathways: the intrinsic pathway and the extrinsic pathway. During the pathogen infection, host cells are capable of eliminating the infected cells through apoptosis. On the other hand, pathogens have evolved a multitude of strategies to regulate host cell apoptosis. These strategies involve the use of effector proteins to modulate cellular signaling pathways, the regulation of the expression of apoptosis-related genes, the control of key proteins within the apoptosis pathway, and the modulation of the activity of proteases in the Caspase family. This article provides a comprehensive review of the molecular mechanisms and strategies by which intracellular pathogens, such as viruses, bacteria, parasitic fungi, and parasites, regulate host cell apoptosis. The aim is to offer valuable references for further exploration of the intricate interaction mechanisms between pathogens and hosts.

apoptosis  /  intracellular pathogens  /  host cells  /  regulatory mechanisms
Maoshuang RAN, Jialing BAO, Guoqing PAN. Research progress in the regulation of host cell apoptosis by intracellular pathogens[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4827 -4841 . DOI: 10.13343/j.cnki.wsxb.20250357
Funding
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  • National Natural Science Foundation of China(32272942)
  • National Natural Science Foundation of China(32272944)
  • Chongqing Modern Agricultural Industry Technology System(COMAITS202311)
  • Fundamental Research Funds for the Central Universities(SWU-XDJH202322)
  • Special Funding for Chongqing Postdoctoral Research Project(2023CQBSHTB3030)
Appendix
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Year 2025 volume 65 Issue 11
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249
92
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Article Info
doi: 10.13343/j.cnki.wsxb.20250357
  • Receive Date：2025-04-29
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
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History
  • Received：2025-04-29
  • Accepted：2025-07-09
Funding
National Natural Science Foundation of China(32272942)
National Natural Science Foundation of China(32272944)
Chongqing Modern Agricultural Industry Technology System(COMAITS202311)
Fundamental Research Funds for the Central Universities(SWU-XDJH202322)
Special Funding for Chongqing Postdoctoral Research Project(2023CQBSHTB3030)
Affiliations
    1 State Key Laboratory of Resource Insects, Southwest University, Chongqing, China
    2 Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China

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*Tel: +86-23-68251683, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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