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Recent advances in phage-antibiotic combination therapy for bacterial infections
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Xuefang REN1, Ruici LU1, Xiaojuan YOU1, Rui ZHU1, 2, *, Yongwei LI1, 2, *
Acta Microbiologica Sinica | 2025, 65(11) : 4780 - 4799
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Acta Microbiologica Sinica | 2025, 65(11): 4780-4799
• Review •
Recent advances in phage-antibiotic combination therapy for bacterial infections
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Xuefang REN1, Ruici LU1, Xiaojuan YOU1, Rui ZHU1, 2, *, Yongwei LI1, 2, *
Affiliations
  • 1 The Second Clinical Medical College of Henan University of Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China
  • 2 Inspection Center of Henan Province Hospital of TCM, Zhengzhou Key Laboratory of Pathogenic Microorganisms and Bacterial Drug Resistance Monitoring, Key Laboratory of Henan Province of Resistant Pathogen Infections Prevention and Therapy by Traditional Chinese Medicine, Zhengzhou, Henan, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250317
Outline
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The spread of antibiotic resistance has made bacterial infections a global public health crisis, posing serious challenges to conventional antibiotic therapy and creating an urgent need to develop novel antibacterial strategies. As viruses are capable of specifically lysing bacteria, phages represent a promising alternative therapeutic strategy due to their unique killing mechanisms and high host specificity. Nevertheless, they face limitations in monotherapy due to their narrow host ranges and the emergence of phage-resistant bacteria. In recent years, phage-antibiotic combination therapy has garnered significant attention. It demonstrates unique advantages in enhancing bactericidal effects, synergistically inhibiting dual-resistance mechanisms, broadening the host range, disrupting biofilms, and treating complex infections. This therapy not only overcomes the limitations of single phage therapy but also paves new avenues for treating multidrug-resistant bacterial infections. This review systematically summarizes the synergistic mechanisms, key influencing factors, current challenges, and optimization strategies of phage-antibiotic combination therapy, aiming to provide a theoretical foundation and practical guidance for further research and clinical translation in this field.

phage therapy  /  phage-antibiotic combination  /  bacterial infection  /  antibiofilm
Xuefang REN, Ruici LU, Xiaojuan YOU, Rui ZHU, Yongwei LI. Recent advances in phage-antibiotic combination therapy for bacterial infections[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4780 -4799 . DOI: 10.13343/j.cnki.wsxb.20250317
Funding
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  • Henan Provincial Science and Technology Research Project(242102310148)
  • Natural Science Foundation of Henan Province(242300420437)
  • Key Scientific Research Project of Henan Higher Education Institutions(24A310007)
  • Key Scientific Research Project of Henan Higher Education Institutions(25A320042)
  • Wu Jieping Medical Foundation Research Special Fund(320.6750.2024-03-27)
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Year 2025 volume 65 Issue 11
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Article Info
doi: 10.13343/j.cnki.wsxb.20250317
  • Receive Date：2025-04-16
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
Affiliations
History
  • Received：2025-04-16
  • Accepted：2025-07-09
Funding
Henan Provincial Science and Technology Research Project(242102310148)
Natural Science Foundation of Henan Province(242300420437)
Key Scientific Research Project of Henan Higher Education Institutions(24A310007)
Key Scientific Research Project of Henan Higher Education Institutions(25A320042)
Wu Jieping Medical Foundation Research Special Fund(320.6750.2024-03-27)
Affiliations
    1 The Second Clinical Medical College of Henan University of Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China
    2 Inspection Center of Henan Province Hospital of TCM, Zhengzhou Key Laboratory of Pathogenic Microorganisms and Bacterial Drug Resistance Monitoring, Key Laboratory of Henan Province of Resistant Pathogen Infections Prevention and Therapy by Traditional Chinese Medicine, Zhengzhou, Henan, China

Corresponding:

*E-mail: LI Yongwei,
ZHU Rui,
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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