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Research progress in the influences of bacterial glycans on infection
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Junyou LIN1, Linfei WANG2, Qiange LIN1, Yilin YE1, Yuxin ZHANG1, Xin QIAN1, Li CHEN3, *, Guiqin SUN1, *
Acta Microbiologica Sinica | 2025, 65(11) : 4763 - 4779
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Acta Microbiologica Sinica | 2025, 65(11): 4763-4779
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Research progress in the influences of bacterial glycans on infection
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Junyou LIN1, Linfei WANG2, Qiange LIN1, Yilin YE1, Yuxin ZHANG1, Xin QIAN1, Li CHEN3, *, Guiqin SUN1, *
Affiliations
  • 1 School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  • 2 The Second People’s Hospital of Linhai, Taizhou, Zhejiang, China
  • 3 Key Laboratory of Medical Molecular Virology of Ministry of Education and National Health Commission, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250292
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Bacterial glycoproteins, glycolipids, and polysaccharides are collectively known as glycans, which can serve as pivotal pathogenic factors leading to infection. Bacterial protein glycosylation mainly includes N-glycosylation, O-glycosylation, S-glycosylation, and arginine glycosylation. Glycolipids and polysaccharides are also important glycoconjugates, mainly including lipopolysaccharides, lipoarabinomannan, rhamnolipids, peptidoglycan, teichoic acids, and capsular polysaccharides. Bacterial glycoconjugates can promote host-pathogen interactions, influencing bacterial virulence, drug resistance, and biofilm formation, thereby facilitating bacterial infection. In addition, bacterial glycoconjugates can exert dual effects by modulating the host immune system: on one hand, aiding bacteria in achieving immune evasion and causing host infection; on the other, activating host immunity to help eliminate bacteria and suppress infection. This article provides an overview of bacterial glycans regarding the types, structural characteristics, roles in bacterial adhesion and colonization, and regulation of host immune responses and summarizes the effects of bacterial glycans on infection, aiming to offer a distinct perspective from glycoimmunology and an alternative strategy for clinical prevention and treatment of bacterial infectious diseases.

bacteria  /  glycans  /  infection  /  glycoproteins  /  glycolipids  /  polysaccharides  /  immune response
Junyou LIN, Linfei WANG, Qiange LIN, Yilin YE, Yuxin ZHANG, Xin QIAN, Li CHEN, Guiqin SUN. Research progress in the influences of bacterial glycans on infection[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4763 -4779 . DOI: 10.13343/j.cnki.wsxb.20250292
Funding
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  • Cooperative Projects Between Zhejiang Chinese Medical University and Linhai Second People’s Hospital(2023-HT-1266)
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Year 2025 volume 65 Issue 11
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Article Info
doi: 10.13343/j.cnki.wsxb.20250292
  • Receive Date：2025-04-09
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
Affiliations
History
  • Received：2025-04-09
  • Accepted：2025-07-08
Funding
Cooperative Projects Between Zhejiang Chinese Medical University and Linhai Second People’s Hospital(2023-HT-1266)
Affiliations
    1 School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
    2 The Second People’s Hospital of Linhai, Taizhou, Zhejiang, China
    3 Key Laboratory of Medical Molecular Virology of Ministry of Education and National Health Commission, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China

Corresponding:

*E-mail: SUN Guiqin,
CHEN Li,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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