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Research progress in attack-defense interaction mechanisms between Streptococcus pneumoniae and host autophagy systems
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Luqing CUI, Jingyan FAN, Hexiang JIANG, Houhui SONG, Yang YANG*
Acta Microbiologica Sinica | 2025, 65(11) : 4752 - 4762
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Acta Microbiologica Sinica | 2025, 65(11): 4752-4762
• Review •
Research progress in attack-defense interaction mechanisms between Streptococcus pneumoniae and host autophagy systems
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Luqing CUI, Jingyan FAN, Hexiang JIANG, Houhui SONG, Yang YANG*
Affiliations
  • Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, Zhejiang, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250290
Outline
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Streptococcus pneumoniae is a common opportunistic pathogen that can cause various infectious diseases, including acute otitis media, bronchitis, sinusitis, community-acquired pneumonia, septicemia, and purulent meningitis. Autophagy, a lysosome-dependent intracellular degradation pathway, plays a dual regulatory role in both bacterial infection and host defense against pathogens. During S. pneumoniae infection, host cells can activate xenophagy to eliminate invading bacteria. However, this pathogen has evolved multiple evasion strategies, such as interfering with autophagosome maturation, escaping autophagic encapsulation, and even hijacking the autophagy pathway to promote intracellular survival and dissemination. Recent years have witnessed significant progress in understanding the molecular mechanisms underlying the dynamic interplay between S. pneumoniae and host autophagy systems during bacterial infection, yet a systematic review synthesizing these findings remains unavailable. This review focuses on the interaction network and key mechanisms of S. pneumoniae with host cell autophagy, aiming to provide theoretical foundations and research perspectives for developing novel targeted therapeutic strategies against S. pneumoniae infections.

Streptococcus pneumoniae  /  autophagy  /  host-pathogen interaction  /  autophagic clearance  /  pathogenic mechanism
Luqing CUI, Jingyan FAN, Hexiang JIANG, Houhui SONG, Yang YANG. Research progress in attack-defense interaction mechanisms between Streptococcus pneumoniae and host autophagy systems[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4752 -4762 . DOI: 10.13343/j.cnki.wsxb.20250290
Funding
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  • Zhejiang Provincial Natural Science Foundation(LQN25C180009)
  • Research and Development Fund for Zhejiang A&F University(2024LFR115)
Appendix
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Year 2025 volume 65 Issue 11
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Article Info
doi: 10.13343/j.cnki.wsxb.20250290
  • Receive Date：2025-04-08
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
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History
  • Received：2025-04-08
  • Accepted：2025-06-21
Funding
Zhejiang Provincial Natural Science Foundation(LQN25C180009)
Research and Development Fund for Zhejiang A&F University(2024LFR115)
Affiliations
    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, Zhejiang, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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