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Research advances in the anti-inflammatory effects of the Lactobacillaceae through the inhibition of the nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 inflammasome activation
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Chengshui LIAO1, 2, *, Yanyan JIA1, 2, Zuhua YU1, 2, Ke DING1, 2
Acta Microbiologica Sinica | 2025, 65(11) : 4736 - 4751
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Acta Microbiologica Sinica | 2025, 65(11): 4736-4751
• Review •
Research advances in the anti-inflammatory effects of the Lactobacillaceae through the inhibition of the nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 inflammasome activation
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Chengshui LIAO1, 2, *, Yanyan JIA1, 2, Zuhua YU1, 2, Ke DING1, 2
Affiliations
  • 1 Laboratory of Functional Microbiology and Animal Health, Henan University of Science and Technology, Luoyang, Henan, China
  • 2 Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China
Published: 2025-11-04 doi: 10.13343/j.cnki.wsxb.20250280
Outline
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The nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 (NLRP3) inflammasome, a crucial element of innate immunity, plays a pivotal role in immune responses and disease pathogenesis. Dysregulated activation of the NLRP3 inflammasome is strongly linked to the onset of various diseases. Recent studies have demonstrated that the Lactobacillaceae can exert anti-inflammatory effects by regulating the NLRP3 inflammasome activity. Therefore, this review outlines the anti-inflammatory mechanisms by which the Lactobacillaceae regulate the NLRP3 inflammasome activity both directly and indirectly. Additionally, we discuss the roles of specific strains, such as Lactiplantibacillus plantarum, Lacticaseibacillus casei, and Lacticaseibacillus rhamnosus, in intestinal inflammatory diseases, hepatic disorders, neurodegenerative diseases, and metabolic/immune-related conditions. This review aims to lay a foundation for an in-depth investigation of the precise mechanisms underlying the Lactobacillaceae-mediated regulation of the NLRP3 inflammasome and provides novel therapeutic strategies for inflammatory diseases.

Lactobacillaceae  /  nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 (NLRP3)  /  inhibition  /  activation  /  inflammation
Chengshui LIAO, Yanyan JIA, Zuhua YU, Ke DING. Research advances in the anti-inflammatory effects of the Lactobacillaceae through the inhibition of the nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3 inflammasome activation[J]. Acta Microbiologica Sinica, 2025 , 65 (11) : 4736 -4751 . DOI: 10.13343/j.cnki.wsxb.20250280
Funding
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  • Natural Science Foundation of Henan Province(242300421107)
  • Youth Backbone Teachers Training Program of Henan Province(2023GGJS049)
  • National Natural Science Foundation of China(32072771)
Appendix
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Year 2025 volume 65 Issue 11
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Article Info
doi: 10.13343/j.cnki.wsxb.20250280
  • Receive Date：2025-04-06
  • Online Date：2025-11-10
  • Published：2025-11-04
Article Data
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History
  • Received：2025-04-06
  • Accepted：2025-07-05
Funding
Natural Science Foundation of Henan Province(242300421107)
Youth Backbone Teachers Training Program of Henan Province(2023GGJS049)
National Natural Science Foundation of China(32072771)
Affiliations
    1 Laboratory of Functional Microbiology and Animal Health, Henan University of Science and Technology, Luoyang, Henan, China
    2 Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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