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Alcoholic liver disease (ALD) is a liver disease caused by long-term excessive alcohol consumption and is one of the most common chronic liver diseases worldwide. At present, no effective approach is available for preventing or reversing this disease, causing a serious social burden and increasing the pressure for prevention and treatment. In recent years, researchers have found that long-term alcohol abuse can lead to significant changes in the structure and function of the gut microbiota, thereby disrupting the balance of the gut microbiota, which can promote the progression of ALD. Therefore, maintaining gut microbiota balance can provide new targets for the prevention and treatment of ALD. This article reviews the research and intervention progress of the gut microbiota and its metabolites in ALD in recent years, providing reference for future studies on the pathogenesis and treatment of this disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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