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Oxidative resistance and infection ability mediated by LPXTG motif-anchored protein Lmo0175 in Listeria monocytogenes
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Hongrui GE1, Haojie LI1, Yujie GAO1, Jiali XU1, Rui ZHANG2, Houhui SONG1, Changyong CHENG1, Simin DENG1
Acta Microbiologica Sinica | 2025, 65(10) : 4504 - 4516
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Acta Microbiologica Sinica | 2025, 65(10): 4504-4516
• Research Article •
Oxidative resistance and infection ability mediated by LPXTG motif-anchored protein Lmo0175 in Listeria monocytogenes
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Hongrui GE1, Haojie LI1, Yujie GAO1, Jiali XU1, Rui ZHANG2, Houhui SONG1, Changyong CHENG1, Simin DENG1
Affiliations
  • 1Key Laboratory of Applied Biotechnology on Green-eco-healthy Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China
  • 2College of Veterinary Medicine, China Agricultural University, Beijing, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250203
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[Objective] To compare the bacterial growth, oxidative resistance, and bacterial infection in cells and host among Listeria monocytogenes EGD-e, lmo0175 (LPXTG motif-anchored protein)-deleted and complementary strains, so as to investigate the roles of Lmo0175 in anti-oxidative resistance and bacterial infection. [Methods] The lmo0175-deleted and complementary strains were constructed to compare the difference in bacterial growth, oxidative resistance, adhesion, invasion, intracellular proliferation, survival of infected mice, and bacterial loads in organs of Listeria monocytogenes. [Results] The deletion of lmo0175 remarkably decreased oxidative resistance, cell proliferation, colonization in the liver and spleen, and pathogenicity in mice. However, it had no significant impact on bacterial growth, adhesion or invasion. [Conclusion] The LPXTG motif-anchored protein Lmo0175 contributes to the anti-oxidative resistance, proliferation, and colonization in specific organs of Listeria monocytogenes.

Listeria monocytogenes  /  oxidative stress  /  host infection  /  LPXTG motif-anchored protein Lmo0175
Hongrui GE, Haojie LI, Yujie GAO, Jiali XU, Rui ZHANG, Houhui SONG, Changyong CHENG, Simin DENG. Oxidative resistance and infection ability mediated by LPXTG motif-anchored protein Lmo0175 in Listeria monocytogenes[J]. Acta Microbiologica Sinica, 2025 , 65 (10) : 4504 -4516 . DOI: 10.13343/j.cnki.wsxb.20250203
Funding
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  • the College Students’ Innovative Entrepreneurial Training Program in Zhejiang Province in 2025
Appendix
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Year 2025 volume 65 Issue 10
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166
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Article Info
doi: 10.13343/j.cnki.wsxb.20250203
  • Receive Date：2025-03-16
  • Online Date：2025-11-03
  • Published：2025-09-04
Article Data
Affiliations
History
  • Received：2025-03-16
  • Accepted：2025-03-25
Funding
the College Students’ Innovative Entrepreneurial Training Program in Zhejiang Province in 2025
Affiliations
    1Key Laboratory of Applied Biotechnology on Green-eco-healthy Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China
    2College of Veterinary Medicine, China Agricultural University, Beijing, China

Corresponding:

E-mail: DENG Simin,
CHENG Changyong,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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