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Research advances on the role and mechanisms of gut microbiota in colorectal cancer therapy
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Xuemei ZHANG1, Min WEI1, Fei XIA1, Hui WANG1, Qibin HE1, Xiaoyi WANG2
Acta Microbiologica Sinica | 2025, 65(10) : 4241 - 4253
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Acta Microbiologica Sinica | 2025, 65(10): 4241-4253
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Research advances on the role and mechanisms of gut microbiota in colorectal cancer therapy
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Xuemei ZHANG1, Min WEI1, Fei XIA1, Hui WANG1, Qibin HE1, Xiaoyi WANG2
Affiliations
  • 1The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • 2School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250062
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Colorectal cancer (CRC) remains a focal point of research due to its consistently high incidence and mortality, as well as the substantial economic and healthcare burdens it imposes. In recent years, the pivotal role of the gut microbiota in the prevention, diagnosis, and treatment of CRC has garnered increasing attention, offering promising avenues for the management of advanced stages of the disease. This article comprehensively reviews the involvement of the gut microbiota in the development and progression of CRC, elucidating the underlying mechanisms. Furthermore, it examines the potential applications of the gut microbiota in the systemic treatment of advanced CRC, with the aim of proposing novel strategies and insights to enhance the diagnosis and treatment of advanced CRC.

gut microbiota  /  colorectal cancer  /  systemic therapy
Xuemei ZHANG, Min WEI, Fei XIA, Hui WANG, Qibin HE, Xiaoyi WANG. Research advances on the role and mechanisms of gut microbiota in colorectal cancer therapy[J]. Acta Microbiologica Sinica, 2025 , 65 (10) : 4241 -4253 . DOI: 10.13343/j.cnki.wsxb.20250062
Funding
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  • the National Natural Science Foundation of China(82402645)
  • the Affiliated Jiangning Hospital of Nanjing Medical University Youth Innovation Research Fund(JNYYZXKY202202)
Appendix
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Year 2025 volume 65 Issue 10
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319
140
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Article Info
doi: 10.13343/j.cnki.wsxb.20250062
  • Receive Date：2025-01-22
  • Online Date：2025-11-03
  • Published：2025-09-04
Article Data
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History
  • Received：2025-01-22
  • Accepted：2025-06-20
Funding
the National Natural Science Foundation of China(82402645)
the Affiliated Jiangning Hospital of Nanjing Medical University Youth Innovation Research Fund(JNYYZXKY202202)
Affiliations
    1The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    2School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China

Corresponding:

E-mail: HE Qibin,
WANG Xiaoyi,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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