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Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans
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Jingxin GAO1, Lingyun LIU2, Xiaoqian LI2, Lijie GUAN2
Acta Microbiologica Sinica | 2026, 66(8) : 3839 - 3850
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Acta Microbiologica Sinica | 2026, 66(8): 3839-3850
• Research Article •
Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans
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Jingxin GAO1, Lingyun LIU2, Xiaoqian LI2, Lijie GUAN2
Affiliations
  • 1.College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
  • 2.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260082
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[Objective] To elucidate the primary bioactive component in Psoralea corylifolia seed extract that is responsible for inhibiting Pseudomonas amygdali pv. lachrymans (Pal) and to characterize its antibacterial mechanism. [Methods] The effect of isopsoralen on the growth curve of Pal and its minimum inhibitory concentration (MIC) were determined by the liquid culture assay. The antibacterial mechanism was investigated by transmission electron microscopy (TEM) combined with physiological and biochemical analyses. [Results] The MIC of isopsoralen against Pal was 400 mg/L. Isopsoralen disrupted the integrity of the bacterial cell wall and cell membrane, leading to leakage of intracellular contents. It interfered with cellular energy metabolism by inhibiting the activity of respiratory chain dehydrogenases. In addition, it impaired bacterial responses to environmental changes and colonization in the host by suppressing swarming motility, swimming motility, and biofilm formation. [Conclusion] Isopsoralen exerts its inhibitory activity against Pal through the synergistic actions of structural damage, energy disruption, and virulence suppression, ultimately abolishing the pathogen’s ability to infect the host. These findings provide a theoretical basis for the application of P. corylifolia seed extract as a botanical bactericide in the green management of cucumber bacterial angular leaf spot.

isopsoralen  /  Pseudomonas amygdali pv. lachrymans  /  physiological and biochemical mechanism
高晶鑫, 刘凌云, 李筱芊, 关丽杰. 异补骨脂素对黄瓜细菌性角斑病菌的抑制活性及作用机制. 微生物学报, 2026 , 66 (8) : 3839 -3850 . DOI: 10.13343/j.cnki.wsxb.20260082
Jingxin GAO, Lingyun LIU, Xiaoqian LI, Lijie GUAN. Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3839 -3850 . DOI: 10.13343/j.cnki.wsxb.20260082
Funding
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  • National Key Research and Development Program of China(SQ2020YFF0411744)
Appendix
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Year 2026 volume 66 Issue 8
530
240
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Article Info
doi: 10.13343/j.cnki.wsxb.20260082
  • Receive Date：2026-01-27
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
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History
  • Received：2026-01-27
  • Accepted：2026-04-13
Funding
National Key Research and Development Program of China(SQ2020YFF0411744)
Affiliations
    1.College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
    2.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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