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Biological functions of serine/threonine kinase phosphorylation substrates in Streptococcus suis serotype 2
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Yutong TIAN1, Ru YAN1, Hang YIN1, Zixuan ZHAO1, Shiqi LANG1, Rendong FANG1, 2
Acta Microbiologica Sinica | 2026, 66(7) : 3203 - 3218
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Acta Microbiologica Sinica | 2026, 66(7): 3203-3218
• Review •
Biological functions of serine/threonine kinase phosphorylation substrates in Streptococcus suis serotype 2
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Yutong TIAN1, Ru YAN1, Hang YIN1, Zixuan ZHAO1, Shiqi LANG1, Rendong FANG1, 2
Affiliations
  • 1.Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China
  • 2.National Center of Technology Innovation for Pigs, Chongqing, China
Published: 2026-07-04 doi: 10.13343/j.cnki.wsxb.20250786
Outline
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Streptococcus suis is a major zoonotic pathogen that can infect both pigs and humans, causing severe diseases such as meningitis in humans. Its pathogenicity depends on the ability to rapidly adapt to environmental stress and host immune responses. Serine/threonine kinases and their corresponding phosphatases constitute a eukaryotic-like signal transduction system in bacteria and play a key regulatory role in S. suis serotype 2, closely related to its biological characteristics and pathogenic mechanisms. Through precise regulation of the phosphorylation and dephosphorylation of downstream substrates, serine/threonine kinases/phosphatases form complex signaling networks, thereby influencing various physiological and pathogenic processes of the bacterium. This article systematically reviews the currently known substrates of serine/threonine kinases in S. suis serotype 2, with a focus on elucidating how these kinases precisely regulate bacterial growth and division, capsule synthesis, stress tolerance, adhesion, invasion, and pathogenicity by modulating the phosphorylation status of functional substrates. This review aims to provide new perspectives for deciphering the pathogenic mechanism of S. suis serotype 2 and the development of novel antibacterial strategies.

serine/threonine kinase/phosphatase  /  phosphorylation  /  Streptococcus suis serotype 2  /  virulence  /  regulatory network
Yutong TIAN, Ru YAN, Hang YIN, Zixuan ZHAO, Shiqi LANG, Rendong FANG. Biological functions of serine/threonine kinase phosphorylation substrates in Streptococcus suis serotype 2[J]. Acta Microbiologica Sinica, 2026 , 66 (7) : 3203 -3218 . DOI: 10.13343/j.cnki.wsxb.20250786
Funding
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  • The National Natural Science Foundation of China(32473027)
  • The National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
  • The Chongqing Modern Agricultural Industry Technology System(CQMAITS202512)
  • The Southwest University Graduate Research Innovation Project(SWUB25087)
Appendix
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Year 2026 volume 66 Issue 7
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148
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Article Info
doi: 10.13343/j.cnki.wsxb.20250786
  • Receive Date：2025-10-20
  • Online Date：2026-07-06
  • Published：2026-07-04
Article Data
Affiliations
History
  • Received：2025-10-20
  • Accepted：2026-02-13
Funding
The National Natural Science Foundation of China(32473027)
The National Center of Technology Innovation for Pigs(NCTIP-XD/C17)
The Chongqing Modern Agricultural Industry Technology System(CQMAITS202512)
The Southwest University Graduate Research Innovation Project(SWUB25087)
Affiliations
    1.Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China
    2.National Center of Technology Innovation for Pigs, Chongqing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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