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Infection ability of LPXTG motif-anchored protein Lmo0130 in Listeria monocytogenes
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Simin DENG, Hongrui GE, Yan SHAN, Minjie MAO, Jiali XU, Jing XIA, Houhui SONG, Changyong CHENG
Acta Microbiologica Sinica | 2025, 65(9) : 4188 - 4197
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Acta Microbiologica Sinica | 2025, 65(9): 4188-4197
• Research Article •
Infection ability of LPXTG motif-anchored protein Lmo0130 in Listeria monocytogenes
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Simin DENG, Hongrui GE, Yan SHAN, Minjie MAO, Jiali XU, Jing XIA, Houhui SONG, Changyong CHENG
Affiliations
  • Key Laboratory of Applied Technology on Green-Eco-Healthy on Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, the Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China
Published: 2025-09-04 doi: 10.13343/j.cnki.wsxb.20250186
Outline
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[Objective] To investigate the role of Listeria monocytogenes LPXTG motif-anchored protein Lmo0130 in infection causing diseases, the bacterial growth, infection in cell and host among the L. monocytogenes wild-type, lmo0130-deleted and lmo0130-complementary strains were compared. [Methods] The lmo0130-deleted strain Δlmo0130 and lmo0130-complementary strain CΔlmo0130 were constructed to investigate the effects of Lmo0130 on the abilities of bacterial growth, cell surface adhesion and invasion, intracellular proliferation, intercellular migration, survival of infected mice, and bacterial load in mouse organs, ultimately demonstrated the role of L. monocytogenes Lmo0130 in cell and host infection. [Results] LPXTG motif-anchored protein Lmo0130 contributed to cell surface adhesion and invasion, intracellular proliferation, specific colonization in the liver and spleen, and pathogenicity in mice. However, it had no effect on bacterial growth or intercellular migration. [Conclusion] Lmo0130 contributes to cell and host infection of L. monocytogenes finally.

LPXTG motif-anchored protein Lmo0130  /  infection causing diseases  /  intracellular proliferation  /  Listeria monocytogenes
邓思敏, 葛泓睿, 单䶮, 毛敏杰, 徐加利, 夏菁, 宋厚辉, 程昌勇. 单核增生李斯特氏菌LPXTG基序锚定蛋白Lmo0130的感染生物学作用. 微生物学报, 2025 , 65 (9) : 4188 -4197 . DOI: 10.13343/j.cnki.wsxb.20250186
Simin DENG, Hongrui GE, Yan SHAN, Minjie MAO, Jiali XU, Jing XIA, Houhui SONG, Changyong CHENG. Infection ability of LPXTG motif-anchored protein Lmo0130 in Listeria monocytogenes[J]. Acta Microbiologica Sinica, 2025 , 65 (9) : 4188 -4197 . DOI: 10.13343/j.cnki.wsxb.20250186
Funding
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  • National Key Research and Development Program of China(2023YFD1801800)
  • National Natural Science Foundation of China(32473026)
  • National Natural Science Foundation of China(32302961)
  • Zhejiang University Students’ Scientific and Technological Innovation Project in 2025(2025R412A011)
  • College Students’ Innovative Entrepreneurial Training Plan Program in Zhejiang Province in 2025
Appendix
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Year 2025 volume 65 Issue 9
612
273
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20250186
  • Receive Date：2025-03-06
  • Online Date：2026-02-07
  • Published：2025-09-04
Article Data
Affiliations
History
  • Received：2025-03-06
  • Accepted：2025-03-31
Funding
National Key Research and Development Program of China(2023YFD1801800)
National Natural Science Foundation of China(32473026)
National Natural Science Foundation of China(32302961)
Zhejiang University Students’ Scientific and Technological Innovation Project in 2025(2025R412A011)
College Students’ Innovative Entrepreneurial Training Plan Program in Zhejiang Province in 2025
Affiliations
    Key Laboratory of Applied Technology on Green-Eco-Healthy on Animal Husbandry of Zhejiang Province, Zhejiang Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, the Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, Zhejiang, China

Corresponding:

*E-mail: CHENG Changyong,
SONG Houhui,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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