Article(id=1261728979304759355, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1778749230456, onlineDateStr=2026-05-14, pubDate=1774195200000, pubDateStr=2026-03-23, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1778749230456, onlineIssueDateStr=2026-05-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1778749230456, creator=13701087609, updateTime=1778749230456, updator=13701087609, issue=Issue{id=1261728796072358112, tenantId=1146029695717560320, journalId=1146119944283992078, year='2026', volume='4', issue='6', pageStart='1', pageEnd='234', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1778749186771, creator=13701087609, updateTime=1778750183088, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1261732975067148479, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1261732975071342784, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=231, endPage=234, ext={CN=ArticleExt(id=1261728982827974744, articleId=1261728979304759355, tenantId=1146029695717560320, journalId=1146119944283992078, language=CN, title=癌胚抗原、神经元特异性烯醇化酶、细胞角蛋白19片段联合检测在肺癌诊断中的价值, columnId=1261728976733594600, journalTitle=实验室检测, columnName=分析与检测, runingTitle=null, highlight=null, articleAbstract=
目的 评估癌胚抗原（carcinoembryonic antigen, CEA）、神经元特异性烯醇化酶（neuron-specific enolase, NSE）和细胞角蛋白19片段（cytokeratin 19 fragment, CYFRA21-1）联合检测在肺癌诊断中的临床意义。
方法 研究选取2022年7月至2025年7月期间就诊于毕节市中医医院的90例肺癌患者作为肺癌组，同期选择90例肺部良性疾病患者作为良性组，并纳入84名健康体检者作为对照组，采用电化学发光免疫分析法分别检测肺癌组、良性组患者胸腔积液及血清中CEA、NSE、CYFRA21-1的水平，同时检测对照组血清中上述3项指标水平并进行比较。
结果 肺癌组胸腔积液及血清中CEA、NSE和CYFRA21-1水平均高于良性组与对照组，差异均具备统计学意义（P<0.05）；病理分型亚组分析显示，NSE水平在小细胞肺癌患者中高于非小细胞肺癌患者（P<0.05）；CYFRA21-1水平在肺鳞癌患者中明显高于小细胞肺癌和肺腺癌患者（P<0.05）；3项指标联合检测对小细胞肺癌、肺鳞癌、肺腺癌等不同病理类型肺癌的诊断敏感性分别为92.9%、91.4%、88.9%，均高于各单项指标检测的敏感性（P<0.05）。
结论 CEA、NSE、CYFRA21-1 3种肿瘤标志物在肺癌患者体内存在异常高表达，且上述标志物的表达具有病理类型特异性，对胸腔积液和血清中CEA、NSE、CYFRA21-1进行联合检测，能够提高肺癌诊断的敏感性，尤其在不同病理类型肺癌的鉴别方面具有重要临床意义。
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