Article(id=1261728973009110009, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1778749228956, onlineDateStr=2026-05-14, pubDate=1774195200000, pubDateStr=2026-03-23, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1778749228956, onlineIssueDateStr=2026-05-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1778749228956, creator=13701087609, updateTime=1778749228956, updator=13701087609, issue=Issue{id=1261728796072358112, tenantId=1146029695717560320, journalId=1146119944283992078, year='2026', volume='4', issue='6', pageStart='1', pageEnd='234', issueExtLink='null', onlineDate='null', pubDate='1774195200000', pubDateStr='2026-03-23', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1778749186771, creator='13701087609', updateTime=1778750183088, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1261732975067148479, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1261732975071342784, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=161, endPage=163, ext={CN=ArticleExt(id=1261728974015741957, articleId=1261728973009110009, tenantId=1146029695717560320, journalId=1146119944283992078, language=CN, title=无水磷酸氢钙粒径对产品性能的影响及标准优化研究, columnId=1152194692738331642, journalTitle=实验室检测, columnName=聚焦话题, runingTitle=null, highlight=null, articleAbstract=
目的 探究无水磷酸氢钙粒径分布对其关键产品性能的影响规律，评估现有粒径检测标准的适用性并提出优化方向。
方法 采用激光衍射法与干湿法、筛分法并行测定不同批次样品的粒径分布参数（D10, D50, D90）；系统考察粒径对休止角（流动性）、粉末压缩成型抗压强度及模拟体液溶出速率的影响；通过多组独立实验（n≥3）获取重复性数据，采用单因素方差分析及Pearson相关性检验进行统计学处理。
结果 激光衍射法测得中位径（D50）为15~45 μm，筛分法显示>75 μm颗粒占比随工艺变化显著（P<0.001）；D50增大至45μm时，休止角由41.5°±1.2°显著降低至27.8°±0.9° （P<0.01），流动性提升约33%；D50减小至15 μm时，片剂抗压强度由（112.7±5.1） N提升至（152.4±6.3） N，增幅达35.2%（P<0.001）；两种粒径检测方法在D90以上区间差异显著（r2=0.83），激光衍射法对小粒径分辨率更优。
结论 粒径是影响无水磷酸氢钙功能特性的核心变量，需建立以D50为核心、兼顾粒度分布跨度（Span）的多维质量标准；推荐激光衍射法作为主检手段，辅以特定孔径筛分法监控粗颗粒；优化目标应平衡流动性与溶出需求，建议将D50控制在20~40 μm范围并限制超大颗粒（>100 μm）比例。
, authors=null, authorsList=杨玉梅, authorCompany=null, correspAuthors=杨玉梅, authorNote=null, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=cwDsXt32wufKwpGILtw3XQ==, magXml=TOSEK2A3gjRuezZtOQ42Kw==, pdfUrl=null, pdf=dt69Bz1+Q945RA67rKl+nw==, pdfFileSize=1410519, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=rsQ8pHlFMBkAyYb6hwh+TQ==, mapNumber=null, fund=null)}, authors=[Author(id=1261729995072913656, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1123221176@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={CN=AuthorExt(id=1261729995173576955, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, authorId=1261729995072913656, language=CN, stringName=杨玉梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=湖南千金协力药业有限公司，株洲 412000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1261729994959667445, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, xref=null, ext=[AuthorCompanyExt(id=1261729994968056054, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, companyId=1261729994959667445, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南千金协力药业有限公司，株洲 412000)])])], keywords=[Keyword(id=1261729995723030780, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, language=CN, orderNo=1, keyword=无水磷酸氢钙), Keyword(id=1261729995941134589, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, language=CN, orderNo=2, keyword=粒径), Keyword(id=1261729996188598526, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, language=CN, orderNo=3, keyword=产品性能), Keyword(id=1261729996838715647, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, language=CN, orderNo=4, keyword=标准优化)], refs=null, funds=null, companyList=[AuthorCompany(id=1261729994959667445, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, xref=null, ext=[AuthorCompanyExt(id=1261729994968056054, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728973009110009, companyId=1261729994959667445, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南千金协力药业有限公司，株洲 412000)])], figs=null, attaches=null, journal=Journal(id=1146118849029578755, delFlag=0, nameCn=实验室检测, nameEn=Laboratory Testing, nameHistory1=null, nameHistory2=null, issn=2097-261X, eissn=, cn=10-1875/TB, coden=null, periodic=0, language=CN, oaType=, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=Dmoi7fiemaDGWUxiXPMi1g==, journalPrice=null, startedYear=null, abbrevIsoEn=Lab Test, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1784016003438, createdBy=null, updatedBy=13041195026, firstLetterCn=S, firstLetterEn=S, subjectCode=Engineering, subjectName=工程, subjectCodeEn=Engineering, subjectNameEn=null, picCn=Dmoi7fiemaDGWUxiXPMi1g==, picEn=1VW7aV1haIq706bPcrSXYQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1283819426399097521, language=CN, name=实验室检测, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784016003465, updatedTime=1784016003465, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=mailto:jlabtesting@126.com, submissionEditorUrl=, submissionReviewUrl=, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1283819426613007026, language=EN, name=Laboratory Testing, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784016003516, updatedTime=1784016003516, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=mailto:jlabtesting@126.com, submissionEditorUrl=, submissionReviewUrl=, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1146119944283992078, websiteList=[Website(id=1148243202374623651, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146119944283992078, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/sysjc/CN, language=CN, createTime=1751692112773, createBy=18614031015, updateTime=1753520557560, updateBy=18614031015, name=实验室检测-中文站点, tplId=1146099689490845704, title=实验室检测, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1260560912239419452, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=articleTextType, value=kx, createTime=1778470741567, updateTime=1778470741567, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912218447929, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=banner, value=null, createTime=1778470741562, updateTime=1778470741562, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912264585279, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=grayFlag, value=0, createTime=1778470741573, updateTime=1778470741573, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912214253624, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=logo, value=https://castjournals.cast.org.cn/joweb/sysjc/CN/file/pic?fileId=gxmh/wpj2QaxtghYq950Aw==, createTime=1778470741561, updateTime=1778470741561, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912277168193, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=minRunFlag, value=0, createTime=1778470741576, updateTime=1778470741576, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912235225147, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/sysjc/CN/file/pic, createTime=1778470741566, updateTime=1778470741566, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912268779584, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=silenceFlag, value=0, createTime=1778470741574, updateTime=1778470741574, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912226836538, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1778470741564, updateTime=1778470741564, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912247808061, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=themeColor, value=null, createTime=1778470741569, updateTime=1778470741569, creator=18614031015, updator=18614031015), WebsiteProps(id=1260560912256196670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=themeStyle, value=null, createTime=1778470741571, updateTime=1778470741571, creator=18614031015, updator=18614031015)])], journalTitle=实验室检测, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Laboratory Testing, journalPhotoCn=Dmoi7fiemaDGWUxiXPMi1g==, journalPhotoEn=1VW7aV1haIq706bPcrSXYQ==, journalFirstLetter=S, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/sysjc/CN/Y2026/V4/I6/161, detailUrlEn=/Y2026/V4/I6/161, pdfUrlCn=https://castjournals.cast.org.cn/joweb/sysjc/CN/PDF/Y2026/V4/I6/161, pdfUrlEn=/PDF/Y2026/V4/I6/161, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1774195200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
51
13
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
