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目的 建立小儿化积颗粒中山楂、牵牛子、槟榔的质量控制方法。
方法 采用薄层色谱法（thin-layer chromatography, TLC）定性鉴别山楂、牵牛子、槟榔，优化展开剂及供试品制备条件；通过高效液相色谱法（high performance liquid chromatography, HPLC）测定熊果酸、牵牛子苷和槟榔碱，考察色谱条件、线性关系、精密度及稳定性。
结果 TLC结果显示山楂、牵牛子、槟榔特征斑点明显，阴性无干扰。HPLC测定表明：熊果酸（0.5~20.0 μg/mL，r=0.9998）、牵牛子苷（1.0~40.0 μg/mL，r=0.9999）、槟榔碱（0.2~8.0 μg/mL，r=0.9997）线性关系良好。精密度相对标准偏差（relative standard deviation, RSD）≤1.2%，24 h稳定性RSD≤1.8%，3批样品含量稳定。
结论 所建立的TLC和HPLC方法专属性强、准确性高，适用于小儿化积颗粒的质量控制。
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