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目的

分析液相色谱-串联质谱法结合化学衍生化技术在血清小分子代谢物标志物筛选中应用的效能。

方法

选取本院2025年3—10月期间,收治入院的80例原发性高血压患者进行研究,采用随机数字表法为观察组和对照组,各40例。对照组单一使用串联质谱技术,观察组在此基础上,联合应用化学衍生化技术分析血清样本,对比两组血清小分子代谢物种类、数量,标志物检测灵敏度与特异性,探究不同代谢物在两组间的浓度差异。

结果

观察组脂质、氨基酸、糖类代谢物数量均高于对照组(P<0.05);观察组检测灵敏度、特异度与准确度均优于对照组(P<0.05);观察组葡萄糖(glucose, GLU)、总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)等指标水平显著低于对照组(P<0.05)。

结论

液相色谱-串联质谱法联合化学衍生化技术的临床应用,能够提高血清小分子代谢物标志物筛选准确性,为疾病早期诊断与病情评估提供科学依据,具有临床应用推广的价值意义。

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液相色谱-串联质谱法结合化学衍生化技术在血清小分子代谢物标志物筛选中的应用研究
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实验室检测 | 创新应用 2026,4(6): 81-84
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液相色谱-串联质谱法结合化学衍生化技术在血清小分子代谢物标志物筛选中的应用研究
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张明*
作者信息
  • 咸宁市妇幼保健院,咸宁 437100
通讯作者:
张明,主管技师,主要研究方向为临床免疫学实验诊断、临床分子实验诊断。E-mail:
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出版时间: 2026-03-23
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目的

分析液相色谱-串联质谱法结合化学衍生化技术在血清小分子代谢物标志物筛选中应用的效能。

方法

选取本院2025年3—10月期间,收治入院的80例原发性高血压患者进行研究,采用随机数字表法为观察组和对照组,各40例。对照组单一使用串联质谱技术,观察组在此基础上,联合应用化学衍生化技术分析血清样本,对比两组血清小分子代谢物种类、数量,标志物检测灵敏度与特异性,探究不同代谢物在两组间的浓度差异。

结果

观察组脂质、氨基酸、糖类代谢物数量均高于对照组(P<0.05);观察组检测灵敏度、特异度与准确度均优于对照组(P<0.05);观察组葡萄糖(glucose, GLU)、总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)等指标水平显著低于对照组(P<0.05)。

结论

液相色谱-串联质谱法联合化学衍生化技术的临床应用,能够提高血清小分子代谢物标志物筛选准确性,为疾病早期诊断与病情评估提供科学依据,具有临床应用推广的价值意义。

液相色谱-串联质谱法  /  化学衍生化技术  /  血清  /  小分子代谢物  /  标志物筛选
张明. 液相色谱-串联质谱法结合化学衍生化技术在血清小分子代谢物标志物筛选中的应用研究. 实验室检测, 2026 , 4 (6) : 81 -84 .

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  • 首发时间:2026-05-14
  • 出版时间:2026-03-23
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    咸宁市妇幼保健院,咸宁 437100

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张明,主管技师,主要研究方向为临床免疫学实验诊断、临床分子实验诊断。E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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