Article(id=1261728799796900075, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1778749187659, onlineDateStr=2026-05-14, pubDate=1774195200000, pubDateStr=2026-03-23, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1778749187659, onlineIssueDateStr=2026-05-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1778749187659, creator=13701087609, updateTime=1778749187659, updator=13701087609, issue=Issue{id=1261728796072358112, tenantId=1146029695717560320, journalId=1146119944283992078, year='2026', volume='4', issue='6', pageStart='1', pageEnd='234', issueExtLink='null', onlineDate='null', pubDate='1774195200000', pubDateStr='2026-03-23', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1778749186771, creator='13701087609', updateTime=1778750183088, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1261732975067148479, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1261732975071342784, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=63, endPage=66, ext={CN=ArticleExt(id=1261728803584356610, articleId=1261728799796900075, tenantId=1146029695717560320, journalId=1146119944283992078, language=CN, title=自采宫颈阴道样本与医采宫颈样本人乳头瘤病毒分型检测的一致性及阳性符合率对比研究, columnId=1151957373175820401, journalTitle=实验室检测, columnName=创新应用, runingTitle=null, highlight=null, articleAbstract=
目的 探讨自采宫颈阴道样本与医采宫颈样本人乳头瘤病毒（human papillomavirus, HPV）分型检测的一致性及阳性符合率。
方法 选取2024年9月—2025年9月在珠海市斗门区侨立中医院检验科接受HPV检测的女性患者400例，均接受阴道自取样和医取样检测，采用实时荧光定量（polymerase chain reaction, PCR）-探针法进行HPV分型检测，采用核酸分型定量法进行病毒载量检测。比较2种取样方式的HPV分型一致性、阳性符合率及病毒载量差异。
结果 自取样组的52型检出率最高（10.50%）；医取样组的52型检出率最高（11.00%）。自取样组的HPV阳性率为45.25%，医取样组为50.00%，两组间HPV阳性率比较，差异无统计学意义（P>0.05）；两者相比，总一致性较高，Kappa为0.885 ［95%置信区间（confidence interval, CI）：0.843~0.927］。400例患者中，接受细胞学检查386例，其中非典型腺细胞（atypical glandular cells-not otherwise specified, AGC-NOS） 1例（0.26%），无明确诊断意义非典型鳞状细胞（atypical squamous cells of undetermined significance, ASCUS） 47例（12.18%），高级别鳞状上皮内病变（high-grade squamous intraepithelial lesion, HSIL） 5例（1.30%）、低级别鳞状上皮内病变（low-grade squamous intraepithelial lesion, LSIL） 20例（5.18%）、未见上皮内病变或恶性病变（negative for intraepithelial lesion or malignancy, NILM） 313例（81.09%）；自取样检出HSIL、LSIL的准确度分别为100.00%、85.00%，医取样检出HSIL、LSIL的准确度分别为100.00%、95.00%。
结论 自采宫颈阴道样本HPV检测与医采宫颈样本HPV检测的阳性率、分型分布近似，可用于子宫颈癌初筛，利于扩大子宫颈癌筛查覆盖率。
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