Article(id=1261728799322943720, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1778749187546, onlineDateStr=2026-05-14, pubDate=1774195200000, pubDateStr=2026-03-23, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1778749187546, onlineIssueDateStr=2026-05-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1778749187546, creator=13701087609, updateTime=1778749187546, updator=13701087609, issue=Issue{id=1261728796072358112, tenantId=1146029695717560320, journalId=1146119944283992078, year='2026', volume='4', issue='6', pageStart='1', pageEnd='234', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1778749186771, creator=13701087609, updateTime=1778750183088, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1261732975067148479, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1261732975071342784, tenantId=1146029695717560320, journalId=1146119944283992078, issueId=1261728796072358112, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=67, endPage=69, ext={CN=ArticleExt(id=1261728802741301499, articleId=1261728799322943720, tenantId=1146029695717560320, journalId=1146119944283992078, language=CN, title=基于环氧化酶2和离子钙结合衔接分子1检测探讨金盏花对慢性不可预见性温应激小鼠神经保护作用, columnId=1151957373175820401, journalTitle=实验室检测, columnName=创新应用, runingTitle=null, highlight=null, articleAbstract=
目的 探讨金盏花提取物对慢性不可预见性温和应激(chronic unpredictable mild stress, CUMS)小鼠的神经保护作用。
方法 将60只C57BL/6雄性小鼠随机分为空白对照组、模型组、金盏花低剂量组、金盏花中剂量组、金盏花高剂量组、阳性对照组,每组10只。采用CUMS方法建立抑郁模型,金盏花各剂量组分别给予50、100、200 mg/kg金盏花提取物灌胃,阳性对照组给予20 mg/kg氟西汀灌胃,连续干预21 d。检测各组小鼠糖水偏好率、旷场实验穿格次数,采用免疫组织化学法检测海马组织环氧化酶2 (cyclooxygenase-2, COX2)、离子钙结合衔接分子1 (ionized calcium binding adaptor molecule 1, IBA1)表达。
结果 模型组糖水偏好率、穿格次数低于空白对照组(P<0.05),COX2、IBA1表达高于空白对照组(P<0.05)。金盏花中、高剂量组糖水偏好率、穿格次数高于模型组(P<0.05),COX2、IBA1表达低于模型组(P<0.05)。
结论 金盏花提取物能够改善CUMS小鼠抑郁样行为,通过抑制神经炎症反应发挥神经保护作用。
, correspAuthors=余婧孜, authorNote=null, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=frzK0gOEwX63KHxlwz67cg==, magXml=9c5Hy7x73pCWHSyD+FlYrQ==, pdfUrl=null, pdf=JZ90AQVXKkqTQlGCe4KusA==, pdfFileSize=1286164, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=9YmCA04dLzqPxvkOc3QORw==, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=余婧孜)}, authors=[Author(id=1261728805245301005, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=748552291@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={CN=AuthorExt(id=1261728806008664341, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, authorId=1261728805245301005, language=CN, stringName=余婧孜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
*, address=华北理工大学心理与精神卫生学院,唐山 611230, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1261728803970232580, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, xref=null, ext=[AuthorCompanyExt(id=1261728803987009797, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, companyId=1261728803970232580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=华北理工大学心理与精神卫生学院,唐山 611230)])])], keywords=[Keyword(id=1261728806893662495, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, language=CN, orderNo=1, keyword=金盏花), Keyword(id=1261728807346647332, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, language=CN, orderNo=2, keyword=慢性不可预见性温和应激), Keyword(id=1261728807833186601, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, language=CN, orderNo=3, keyword=环氧化酶2), Keyword(id=1261728809917755700, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, language=CN, orderNo=4, keyword=离子钙结合衔接分子1), Keyword(id=1261728811041829177, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, language=CN, orderNo=5, keyword=神经保护)], refs=null, funds=null, companyList=[AuthorCompany(id=1261728803970232580, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, xref=null, ext=[AuthorCompanyExt(id=1261728803987009797, tenantId=1146029695717560320, journalId=1146119944283992078, articleId=1261728799322943720, companyId=1261728803970232580, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=华北理工大学心理与精神卫生学院,唐山 611230)])], figs=null, attaches=null, journal=Journal(id=1146118849029578755, delFlag=0, nameCn=实验室检测, nameEn=Laboratory Testing, nameHistory1=null, nameHistory2=null, issn=2097-261X, eissn=, cn=10-1875/TB, coden=null, periodic=0, language=CN, oaType=是, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=Dmoi7fiemaDGWUxiXPMi1g==, journalPrice=null, startedYear=null, abbrevIsoEn=Lab Test, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1778470330175, createdBy=null, updatedBy=18614031015, firstLetterCn=L, firstLetterEn=L, subjectCode=Engineering, subjectName=工程, subjectCodeEn=Engineering, subjectNameEn=null, picCn=Dmoi7fiemaDGWUxiXPMi1g==, picEn=1VW7aV1haIq706bPcrSXYQ==, jcr=null, cjcr=null, exts=[JournalExt(id=1208043431218225520, language=CN, name=实验室检测, nameHistory1=null, nameHistory2=null, managedBy=国家市场监督管理总局, sponsoredBy=中国检验检测学会, publishedBy=《实验室检测》编辑部, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=《实验室检测》(国内统一刊号: CN 10-1875/TB, 国际标准刊号: ISSN 2097-261X, 半月刊), 创刊于2023年5月, 由国家市场监督管理总局主管, 中国检验检测学会主办, 是一本国内外公开发行, 专注于实验室检测类的学术期刊。现已被《中国学术期刊网络出版总库》(CNKI)、“万方数据 数字化期刊群”等数据库全文收录。主要包括以下栏目: (1) 聚焦话题;(2) 热点解读;(3) 合规咨讯;(4) 研究前沿;(5) 创新应用;(6) 评价与分析;(7) 科创平台;(8) 标准推广, submitArticleUrl=null, websiteUrl=, createdTime=1765949598364, updatedTime=1765949598364, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=, submissionEditorUrl=, submissionReviewUrl=, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1208043431264362865, language=EN, name=Laboratory Testing, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1765949598375, updatedTime=1765949598375, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=, submissionEditorUrl=, submissionReviewUrl=, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1146119944283992078, websiteList=[Website(id=1148243202374623651, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146119944283992078, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/sysjc/CN, language=CN, createTime=1751692112773, createBy=18614031015, updateTime=1753520557560, updateBy=18614031015, name=实验室检测-中文站点, tplId=1146099689490845704, title=实验室检测, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155912534570950828, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=articleTextType, value=kx, createTime=1753520624058, updateTime=1753520624058, creator=18614031015, updator=18614031015), WebsiteProps(id=1155912534554173609, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=banner, value=null, createTime=1753520624054, updateTime=1753520624054, creator=18614031015, updator=18614031015), WebsiteProps(id=1155912534545785000, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=gxmh/wpj2QaxtghYq950Aw==, createTime=1753520624052, updateTime=1753520624052, creator=18614031015, updator=18614031015), WebsiteProps(id=1155912534562562219, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1753520624056, updateTime=1753520624056, creator=18614031015, updator=18614031015), WebsiteProps(id=1155912534558367914, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1148243202374623651, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1753520624055, updateTime=1753520624055, creator=18614031015, updator=18614031015)])], journalTitle=实验室检测, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Laboratory Testing, journalPhotoCn=Dmoi7fiemaDGWUxiXPMi1g==, journalPhotoEn=1VW7aV1haIq706bPcrSXYQ==, journalFirstLetter=L, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/sysjc/CN/Y2026/V4/I6/67, detailUrlEn=/Y2026/V4/I6/67, pdfUrlCn=https://castjournals.cast.org.cn/joweb/sysjc/CN/PDF/Y2026/V4/I6/67, pdfUrlEn=/PDF/Y2026/V4/I6/67, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)