Viscous drag is one of the main sources of civil aircraft drag, and turbulent drag plays a dominant role in viscous drag, so it is of great engineering and scientific significance to carry out turbulence drag reduction control. In this paper, under the condition of a zero pressure gradient experiment, the drag reduction control of the plate boundary layer with isotropic permeating materials fused with micro-blowing is studied. The results show that the isotropic permeable material can significantly reduce the friction drag of the plate surface, and the maximum local drag reduction rate in this paper can reach 55.4%. In addition, compared with the control of a single isotropic permeable material, the isotropic permeating material integrated with micro-blowing not only improves the drag reduction rate in the local region but also increases the flow area of the downstream drag reduction region due to the “memory" of the influence of micro-blowing on the turbulent structure, improving the efficiency of drag reduction. Hot-wire velocity measurement results show that the isotropic permeable material with microblowing can reduce the velocity gradient of the viscous bottom layer of the boundary layer and reduce the momentum exchange between the inner and outer layers. The flow visualization technology of Time-Resolved Particle Image Velocimetry (TR−PIV) showed that the isotropic permeable material integrated with micro-blowing could increase the thickness of the turbulent boundary layer and the pulsation intensity of the flow direction. At the same time, the large-scale high-speed strip structure in the steam-wise direction break down into small-scale structure. The self-holding process and sweeping process near the wall are suppressed, thus achieving drag reduction.