Due to its late discovery, wide distribution, large reserves, complex composition, and low grade, the comprehensive development and utilization of clay type lithium mines still lack systematic research. A systematic study was conducted on the optimization of enhanced leaching process parameters for clay type lithium ore in Liuzhi Special District, Liupanshui City, Guizhou Province. The effects of roasting process conditions such as roasting temperature and time, as well as the effects of leaching process conditions such as leaching agent hydrochloric acid concentration, leaching temperature and time, stirring speed, and liquid volume to solid mass ratio on the experimental results were investigated. The results show that roasting can destroy the crystal lattice of minerals such as kaolinite, superphosphate, diopside, and lithium chlorite in clay type lithium ores, which is beneficial for the sufficient contact between lithium containing phases and leaching agents during subsequent leaching processes, thereby improving their leaching efficiency;After high-temperature roasting at 600 ℃ for 90 min, the clay type lithium ore was subjected to optimal leaching conditions of 60 min, leaching temperature of 80 ℃, hydrochloric acid concentration of 4 mol/L, stirring speed of 400 r/min, and liquid volume to solid mass ratio of 6∶1. The lithium leaching rate can reach 93.48% and the leaching effect is good. The method does not require any additives during the calcination process, which can reduce pollution and lower costs. It has certain promotion and application value.