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A comprehensive undergraduate experiment: development of a dispersive solid-phase extraction method based on halogen-bonded organic frameworks and its application to the analysis of brominated flame retardants
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Dandan WANG, Jiaqi HU, Cui QIN, Mingyue WANG, Famin KE, Hong NIU, Xilin YANG, Die GAO*
Chinese Journal of Chromatography | 2026, 44(10) : 1251 - 1261
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Chinese Journal of Chromatography | 2026, 44(10): 1251-1261
• Teaching Research •
A comprehensive undergraduate experiment: development of a dispersive solid-phase extraction method based on halogen-bonded organic frameworks and its application to the analysis of brominated flame retardants
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Dandan WANG, Jiaqi HU, Cui QIN, Mingyue WANG, Famin KE, Hong NIU, Xilin YANG, Die GAO*
Affiliations
  • 1School of Pharmacy, Southwest Medical University, Luzhou 646000, China
Published: 2026-10-08 doi: 10.3724/SP.J.1123.2026.04016
Outline
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To address the evolving demands for innovation and practical competencies in pharmaceutical education, and in alignment with the “student-centered, outcome-driven” pedagogical approach, our teaching team has undertaken a comprehensive reform of the Pharmaceutical Analysis curriculum. We designed and implemented an integrative, research-based laboratory experiment for undergraduate students. Centered on the design and application of functional materials, the experiment guides students through the independent synthesis of a halogen-bonded organic framework, designated as XOF-1, followed by systematic structural characterization, performance evaluation, and analytical application. The experiment is grounded in real-world environmental analysis challenges, requiring students to employ the synthesized material as a dispersive solid-phase extraction (DSPE) adsorbent for the selective enrichment of typical brominated flame retardants, including tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA), and hexabromobenzene (HBB), and to achieve the removal of TBBPA from actual water samples. The instructional process fully encompasses the workflow from material preparation and structural characterization to method development and performance assessment, enabling students to experience a complete research pathway from material design to practical application. This approach immerses them in the scientific inquiry cycle of theory-design-experiment-analysis. Through this experiment, students gain solid proficiency in synthesizing and characterizing functional materials and applying them to sample pretreatment. By engaging in experimental design, condition optimization, and data interpretation, they develop critical thinking, problem-solving skills, and capacity for independent inquiry. The exercise fosters deep integration of theoretical knowledge and practical skills, stimulates research interest, strengthens innovative and applied mindsets, and cultivates a sense of professional responsibility in environmental and public health. Ultimately, it achieves a cohesive blend of knowledge acquisition, competency development, and value cultivation, fulfilling the overarching goal of holistic education through experimental learning.

comprehensive experiment  /  pharmaceutical analysis  /  halogen-bonded organic frameworks  /  dispersive solid-phase extraction  /  brominated flame retardants
王丹丹, 胡佳绮, 秦翠, 王明月, 柯发敏, 牛红, 杨熙霖, 高蝶. 本科生综合实验:基于卤键有机框架材料的分散固相萃取方法构建及在溴代阻燃剂分析中的应用. 色谱, 2026 , 44 (10) : 1251 -1261 . DOI: 10.3724/SP.J.1123.2026.04016
Dandan WANG, Jiaqi HU, Cui QIN, Mingyue WANG, Famin KE, Hong NIU, Xilin YANG, Die GAO. A comprehensive undergraduate experiment: development of a dispersive solid-phase extraction method based on halogen-bonded organic frameworks and its application to the analysis of brominated flame retardants[J]. Chinese Journal of Chromatography, 2026 , 44 (10) : 1251 -1261 . DOI: 10.3724/SP.J.1123.2026.04016
  • National Natural Science Foundation of China (No. 22474114); Educational Science Research Project of Sichuan Province (No. SCJG25C196); National Research Project on Graduate Education in Traditional Chinese Medicine (No. YJS-YB-2024-78); School-level Project of Southwest Medical University (No. 2024SKLYB14); School-level Education Reform Project of Southwest Medical University (Nos. JG2024145, ZYTS-53, JG2024143).
Year 2026 volume 44 Issue 10
31
11
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Article Info
doi: 10.3724/SP.J.1123.2026.04016
  • Receive Date:2026-04-20
  • Online Date:2026-10-29
  • Published:2026-10-08
Article Data
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History
  • Received:2026-04-20
Funding
National Natural Science Foundation of China (No. 22474114); Educational Science Research Project of Sichuan Province (No. SCJG25C196); National Research Project on Graduate Education in Traditional Chinese Medicine (No. YJS-YB-2024-78); School-level Project of Southwest Medical University (No. 2024SKLYB14); School-level Education Reform Project of Southwest Medical University (Nos. JG2024145, ZYTS-53, JG2024143).
Affiliations
    1School of Pharmacy, Southwest Medical University, Luzhou 646000, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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