收藏切换
Integrated pharmaceutical innovation experiment: preparation of molecularly imprinted polymers and the application in sample pretreatment for in vivo drug analysis
收藏切换
Yuanyuan JIANG1, Ruiling GUO2, Zhihua SONG1, Zongliang LIU1, Yutong FAN1, Hui XU1, *
Chinese Journal of Chromatography | 2026, 44(5) : 589 - 596
Less
收藏切换
Chinese Journal of Chromatography | 2026, 44(5): 589-596
• Teaching Research •
Integrated pharmaceutical innovation experiment: preparation of molecularly imprinted polymers and the application in sample pretreatment for in vivo drug analysis
Full
Yuanyuan JIANG1, Ruiling GUO2, Zhihua SONG1, Zongliang LIU1, Yutong FAN1, Hui XU1, *
Affiliations
  • 1School of Pharmacy, Yantai University, Yantai 264005, China
  • 2School of Food and Bioengineering, Yantai Institute of Technology, Yantai 264003, China
Published: 2026-05-08 doi: 10.3724/SP.J.1123.2025.08009
Outline
收藏切换

Under new pharmaceutical science initiatives and innovation training, we address complex biological sample analysis. A comprehensive pharmaceutical experiment was designed for this purpose. It integrates pharmaceutical analysis, polymer chemistry, and analytical chemistry. Advanced molecular imprinting technology (MIT) serves as the key tool. Cholic acid, a significant endogenous metabolite, is selected as the template. Cholic acid molecularly imprinted polymers (CA-MIPs) are synthesized via precipitation polymerization. Their structure is characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The imprinting site and formation mechanism is elucidated. Adsorption performance is evaluated by high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS). Selectivity and enrichment efficiency in plasma are assessed. The experiment covers material design, synthesis, and characterization. It also includes application performance evaluation. This demonstrates high-level innovation and challenge. The practice enhances students’ innovative thinking and practical skills. It fosters social and professional responsibility. The project cultivates high-quality applied pharmaceutical talents. This represents a beneficial practice in holistic education.

comprehensive pharmaceutical innovation experiment  /  molecularly imprinted polymers (MIPs)  /  biological sample pretreatment  /  structural characterization  /  efficiency evaluation
姜媛媛, 郭瑞玲, 宋志花, 刘宗亮, 范雨彤, 许卉. 药学综合创新实验:分子印迹聚合物制备及其在体内药物分析样品前处理中的应用. 色谱, 2026 , 44 (5) : 589 -596 . DOI: 10.3724/SP.J.1123.2025.08009
Yuanyuan JIANG, Ruiling GUO, Zhihua SONG, Zongliang LIU, Yutong FAN, Hui XU. Integrated pharmaceutical innovation experiment: preparation of molecularly imprinted polymers and the application in sample pretreatment for in vivo drug analysis[J]. Chinese Journal of Chromatography, 2026 , 44 (5) : 589 -596 . DOI: 10.3724/SP.J.1123.2025.08009
Year 2026 volume 44 Issue 5
43
19
Cite this Article
BibTeX
Article Info
doi: 10.3724/SP.J.1123.2025.08009
  • Receive Date:2025-08-11
  • Online Date:2026-10-27
  • Published:2026-05-08
Article Data
Affiliations
History
  • Received:2025-08-11
Affiliations
    1School of Pharmacy, Yantai University, Yantai 264005, China
    2School of Food and Bioengineering, Yantai Institute of Technology, Yantai 264003, China
References
Share
https://castjournals.cast.org.cn/joweb/sepu/EN/10.3724/SP.J.1123.2025.08009
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT