Research

Research ›› 2025, Vol. 8 ›› Issue (11) : 1002 - . DOI: 10.34133/research.1002

Research Article

CCL26–CX3CR1 Axis Mediates a Feedback Loop between Cancer Cell and PMN-MDSCs to Promote CD8⁺ T Cell Exhaustion during Stomach Carcinogenesis

Xiaotao Jiang ¹^,² ,
Hui Wu ¹^,² ,
Ning Yan ¹^,² ,
Anzhou Wu ¹^,² ,
Xianzhe Wang ¹^,² ,
Yi Wen ³ ,
Jinqi An ¹^,² ,
Jingming Chen ¹^,² ,
Jiaxing Yan ¹^,² ,
Changlong Wang ¹^,² ,
Yushan Zou ³ ,
Yuancheng Huang ⁴ ,
Wei Wang ²^,⁵^,^* ,
Peiwu Li ⁶^,^* ,
Kunhai Zhuang ³^,⁷^,^* ,
Yufeng Liu ⁸^,^* ,
Fengbin Liu ³^,⁷^,⁹^,^*

Author information +

¹First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.

²Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.

³The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.

⁴Department of Oncology, Dongguan People’s Hospital (The Tenth Affiliated Hospital of Southern Medical University), Dongguan 523000, Guangdong, China.

⁵Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.

⁶Department of Hepatobiliary Diseases, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou 510405, Guangdong, China.

⁷Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510470, Guangdong, China.

⁸Center for Medical Research on Innovation and Translation, Guangzhou First People’s Hospital, Guangzhou 510180, Guangdong, China.

⁹Lingnan Institute of Spleen and Stomach Diseases, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.

^* Address correspondence to: wangwei16400@163.com (W.W.);

doctorlipw2@163.com (P.L.);

sea-zhuang007@163.com (K.Z.);

eyyufengliu@scut.edu.cn (Y.L.);

liufengbin163@163.com (F.L.)

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Received	Accepted	Published
2025-07-23	2025-11-04
Issue Date
2026-11-02

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