Research

Research ›› 2023, Vol. 6 ›› Issue (4) : 0124 - . DOI: 10.34133/research.0124

Research Article

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19

Xiaoying Ma ¹^,²^,³ ,
Jady Liang ²^,⁴ ,
Guangheng Zhu ²^,³^,⁵ ,
Preeti Bhoria ¹^,²^,³^,⁵ ,
Aron A. Shoara ²^,³^,⁴ ,
Daniel T. MacKeigan ²^,³^,⁴ ,
Christopher J. Khoury ¹^,²^,³ ,
Sladjana Slavkovic ¹^,²^,⁵^,⁶ ,
Lisha Lin ²^,³ ,
Danielle Karakas ¹^,²^,³ ,
Ziyan Chen ¹^,²^,³^,⁶ ,
Viktor Prifti ¹^,²^,³ ,
Zhenze Liu ¹^,²^,³ ,
Chuanbin Shen ¹^,²^,³ ,
Yuchong Li ²^,⁷ ,
Cheng Zhang ⁵^,⁸ ,
Jiayu Dou ²^,³ ,
Zack Rousseau ¹^,²^,³ ,
Jiamin Zhang ¹^,²^,³ ,
Tiffany Ni ¹^,²^,³ ,
Xi Lei ²^,³^,⁵ ,
Pingguo Chen ¹^,²^,³^,⁶ ,
Xiaoyu Wu ⁹ ,
Hamed Shaykhalishahi ²^,³^,⁵ ,
Samira Mubareka ¹^,¹⁰ ,
Kim A. Connelly ²^,¹¹^,¹² ,
Haibo Zhang ²^,⁷^,¹⁰^,¹³^,¹⁴ ,
Ori Rotstein ²^,¹⁵ ,
Heyu Ni ¹^,²^,³^,⁴^,⁵^,⁶^,¹¹^,^*

Author information +

¹Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

²Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Toronto, ON, Canada.

³Toronto Platelet Immunobiology Group, Toronto, ON, Canada.

⁴Department of Physiology, University of Toronto, Toronto, ON, Canada.

⁵CCOA Therapeutics Inc., Toronto, ON, Canada.

⁶Canadian Blood Services Centre for Innovation, Toronto, ON, Canada.

⁷The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

⁸Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

⁹Advanced Pharmaceutics & Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

¹⁰Department of Medical Microbiology and Infectious Disease, Sunnybrook Health Science Centre, Toronto, ON, Canada.

¹¹Department of Medicine, University of Toronto, Toronto, ON, Canada.

¹²Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada.

¹³Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

¹⁴Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

¹⁵Department of Surgery, University of Toronto, Toronto, ON, Canada.

^* Address correspondence to: Heyu.Ni@unityhealth.to

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Received	Accepted	Published
2022-12-20	2023-03-28
Issue Date
2026-10-28

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