Research

Research ›› 2023, Vol. 6 ›› Issue (11) : 0269 - . DOI: 10.34133/research.0269

Research Article

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

Xiujuan Du ¹^,²^,³^,⁴ ,
Yuhua Yan ¹^,²^,⁵^,⁶ ,
Juehua Yu ¹^,²^,⁷ ,
Tailin Zhu ¹^,²^,⁵^,⁸ ,
Chu-Chung Huang ⁹ ,
Lingli Zhang ¹^,² ,
Xingyue Shan ¹^,²^,⁵ ,
Ren Li ³^,⁴ ,
Yuan Dai ¹^,² ,
Hui Lv ¹^,² ,
Xiao-Yong Zhang ³^,⁴ ,
Jianfeng Feng ³^,⁴ ,
Wei-Guang Li ⁶^,^* ,
Qiang Luo ³^,⁴^,^* ,
Fei Li ¹^,²^,⁸^,^*

Author information +

¹Developmental and Behavioral Pediatric Department, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

²Developmental and Behavioral Pediatric Department, Shanghai Xinhua Children’s Hospital, Shanghai 200092, China.

³National Clinical Research Center for Aging and Medicine at Huashan Hospital, Institute of Science and Technology for Brain-Inspired Intelligence, Ministry of Education-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.

⁴State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science and Human Phenom Institute, Fudan University, Shanghai 200032, China.

⁵Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Life Sciences, East China Normal University, Shanghai 200062, China.

⁶Department of Rehabilitation Medicine, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.

⁷Center for Experimental Studies and Research, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

⁸Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai 201210, China.

⁹Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.

^* Address correspondence to: feili@shsmu.edu.cn (F.L.)

qluo@fudan.edu.cn (Q.L.)

liwg@fudan.edu.cn (W.-G.L.)

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Received	Accepted	Published
2023-08-05	2023-10-19
Issue Date
2026-10-28

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