Research

Research ›› 2026, Vol. 9 ›› Issue (8) : 1329 - . DOI: 10.34133/research.1329

RESEARCH ARTICLE

An Emodin-Depot Microsphere-in-Hydrogel Reprograms the Immuno-myogenic Niche to Enable Volumetric Muscle Loss Repair Revealed by Single-Cell Profiling

Wanshun Liu ¹ ,
Ruizhe Wang ² ,
Fu Zhao ³ ,
Zhengyuan Fang ⁴ ,
Jun Ma ⁵ ,
Zhixuan Mai ⁶ ,
Yanwei He ⁷ ,
Junzhe Sheng ² ,
Yunxuan Shi ⁸ ,
Zhijie Zhao ⁹ ,
Hongling Jia ⁸ ,
Xiaojing Wang ¹⁰ ,
Wei Luo ⁶^,⁷ ,
Renwen Wan ⁶^,⁷ ,
Shiyi Chen ⁶^,⁷ ,
Gang Chen ⁵^,^* ,
Qi Sun ⁹^,^* ,
Zhiwen Luo ⁵^,⁶^,⁷^,¹¹^,¹²^,^* ,
Xinming Ye ¹²^,^* ,
Nirong Bao ¹²^,^* ,
Xiaochuan Gu ¹³^,^*

Author information +

¹Department of Sports Medicine, Nanjing Hospital of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

²Spine Center, Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.

³School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.

⁴Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

⁵Department of Orthopaedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.

⁶Fudan University–Dr. Kong Joint Research Center for Sports Medicine and Health Footwear, Fudan University Institute of Sports Medicine (Jinqiao Laboratory), Zhangjiang Institute, Fudan University, Shanghai, China.

⁷Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

⁸College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.

⁹Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

¹⁰Department of Rheumatology and Immunology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

¹¹School of Sports Science and Engineering/Research Institute of Health Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

¹²Department of Orthopedics, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

¹³Department of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.

^* Address correspondence to: adcyy@aliyun.com (G.C.);

^* Address correspondence to: melissahtaylorz84@gmail.com (Q.S.);

^* Address correspondence to: zhiwen.luo_fudan@hotmail.com (Z.L.);

^* Address correspondence to: tyxm@ecust.edu.cn (X.Y.);

^* Address correspondence to: bao.nirong@nju.edu.cn (N.B.);

^* Address correspondence to: xiaochuangu@hotmail.com (X.G.)

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Received	Accepted	Published
2026-02-08	2026-05-28
Issue Date
2026-10-16

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