Research

Research ›› 2026, Vol. 9 ›› Issue (4) : 1233 - . DOI: 10.34133/research.1233

RESEARCH ARTICLE

Myokine Cathepsin B as a Key Muscle–Brain Axis Regulator Mediates Treadmill-Running-Induced Hippocampal Neurogenesis and Cognitive Improvement in Mice

Xuchang Zhou ¹ ,
Dongxue Wang ² ,
Huili Deng ³ ,
Jianmin Guo ⁴ ,
Xier Chen ¹^,⁵ ,
Zhangyu Lin ¹^,⁵ ,
Baolong Liu ⁶ ,
Ruobing Zhao ⁷ ,
Lu Gao ¹ ,
Xuan Yin ² ,
Yun Zhang ¹^,⁸ ,
Yan Chen ¹ ,
Yajing Yang ¹^,⁹ ,
Qingxian Li ¹⁰ ,
Qu Shen ³ ,
Jianguang Ji ²^,^* ,
Guoxin Ni ¹^,^*

Author information +

¹Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China.

²Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.

³School of Medicine, Xiamen University, Xiamen 361102, China.

⁴Institute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.

⁵School of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.

⁶Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110122, China.

⁷Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China.

⁸Medical College, Guangxi University, Nanning 53004, China.

⁹College of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.

¹⁰Department of Orthopedic Surgery, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China.

^* Address correspondence to: jianguangji@um.edu.mo (J.J.);

^* Address correspondence to: nigx@xmu.edu.cn (G.N.)

收起

Received	Accepted	Published
2025-11-20	2026-03-12
Issue Date
2026-10-16

Accesses

Total: 90

	Just accepted	Online first	Issue	Totals
HTML pages views	0	0	78	78
PDF downloads	0	0	12	12

Accesses in the last 12 months

Accesses come from

Citations

Citation counts are provided from Web of Science and CrossRef. The counts may vary by service, and are reliant on the availability of their data. Counts will update daily once available.

Search

Online attention

The hierarchy quorum sensing network in Pseudomonas aeruginosa

Full Text HTML

PDF (59941KB)

Recommended