Research

Research ›› 2026, Vol. 9 ›› Issue (2) : 1161 - . DOI: 10.34133/research.1161

RESEARCH ARTICLE

Repurposed Acarbose Targets Nidogen-1 to Remodel the Tumor Stroma and Suppress Portal Vein Tumor Thrombus in Hepatocellular Carcinoma

Tao Han ¹ ,
Lujun Chen ² ,
Ning Liu ³ ,
Ying chen Han ¹ ,
Zhi Zhu ⁴ ,
Shuyi Wang ¹ ,
Haoran Song ¹ ,
Ziming Gao ⁴ ,
Lin Su ⁵ ,
Qilin Hu ¹ ,
Linda Hammerich ⁶ ,
Timothy M. Pawlik ⁷ ,
Yuhan Zhang ⁸ ,
Masatoshi Kudo ⁹ ,
Hao Li ¹⁰ ,
Lei Ma ¹ ,
Giorgio Valabrega ¹¹ ,
Guang Wang ¹² ,
Zhengqiang Yang ¹³ ,
Qiuhua Luo ¹⁴ ,
Donatella Marino ¹¹ ,
Zihang Xu ⁵^,^* ,
Meng Niu ¹⁵^,^* ,
Tingsong Chen ¹⁶^,^* ,
Heming Li ¹^,^* ,
Kai Li ⁴^,¹⁷^,^*

Author information +

¹Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.

²Laboratory of Gastrointestinal Onco-Pathology, Cancer Institute and General Surgery Institute, The First Hospital of China Medical University, Shenyang, China.

³Department of Pancreatic and Biliary Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.

⁴Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.

⁵Shanghai Key Laboratory of Health Identification and Assessment, School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

⁶Department of Hepatology and Gastroenterology, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.

⁷Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

⁸Shenzhen Engineering Center for Translational Medicine of Precision Cancer Immunodiagnosis and Therapy, YuceBio Technology Co., Ltd, Shenzhen, China.

⁹Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.

¹⁰Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.

¹¹Department of Oncology, University of Turin, Medical Oncology, Ordine Mauriziano Hospital, Turin, Italy.

¹²Department of Hepatobiliary Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.

¹³Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

¹⁴Department of Pharmacy, The First Hospital of China Medical University, Shenyang, Liaoning, China.

¹⁵Department of Interventional Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

¹⁶Department of Interventional Oncology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

¹⁷Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Hospital of China Medical University, Shenyang, China.

^* Address correspondence to: xuzihang6207@shutcm.edu.cn (Z.X.);

^* Address correspondence to: 13998217255@163.com (M.N.);

^* Address correspondence to: cts552052597@163.com (T.C.);

^* Address correspondence to: liheming8563@hotmail.com (H.L.);

^* Address correspondence to: kli@cmu.edu.cn (K.L.)

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Received	Accepted	Published
2025-11-20	2026-01-31
Issue Date
2026-10-16

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