Research

Research ›› 2026, Vol. 9 ›› Issue (3) : 1165 - . DOI: 10.34133/research.1165

REVIEW ARTICLE

3D Cardiac Constructs in Drug Discovery: Current Advances and Future Challenges

Chang Liu ¹^,² ,
Jing Guo ¹^,² ,
Gunash Mirzayeva ¹^,² ,
Michail Spanos ³^,⁴ ,
Ruoting Teng ¹^,² ,
Guoping Li ³ ,
Dragos Cretoiu ⁵^,⁶ ,
Zhaoyang Chen ⁷^,^* ,
Junjie Xiao ¹^,²^,^*

Author information +

¹Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China.

²Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai 200444, China.

³Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

⁴Department of Internal Medicine, Albert Einstein College of Medicine, NCB, Bronx, NY, USA.

⁵Department of Medical Genetics, Carol Davila University of Medicine and Pharmacy, Bucharest 020031, Romania.

⁶Materno-Fetal Assistance Excellence Unit, Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest 011062, Romania.

⁷Department of Cardiology, Heart Center of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.

^* Address correspondence to: chenzhaoyang888@126.com (Z.C.);

^* Address correspondence to: junjiexiao@shu.edu.cn (J.X.)

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Received	Accepted	Published
2025-11-27	2026-02-01
Issue Date
2026-10-16

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