Directed Evolution of T7 RNA Polymerase Minimizes dsRNA By-product and Enables High-Fidelity mRNA Synthesis for Demanding Therapeutic Applications
1State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
2Hzymes Biotechnology Co., Ltd., Wuhan, Hubei 430010, China.
3Institute of Key Biological Raw Material, Shanghai Academy of Experimental Medicine, Shanghai 201401, China.
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