Research

Research ›› 2026, Vol. 9 ›› Issue (2) : 1128 - . DOI: 10.34133/research.1128

REVIEW ARTICLE

Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer

Junjiang Ye ¹^,² ,
Yandong Xie ³ ,
Jie Wang ² ,
Ruicheng Wu ²^,⁴ ,
Dengxiong Li ⁵ ,
Koo Han Yoo ⁶ ,
Dilinaer Wusiman ⁷ ,
William C. Cho ⁸^,^* ,
Zhaojie Lyu ⁹^,^* ,
Dechao Feng ¹^,⁴^,^*

Author information +

¹Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, 310014 Zhejiang, China.

²Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

³Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

⁴Division of Surgery and Interventional Science, University College London, London W1W 7TS, UK.

⁵Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China.

⁶Department of Urology, Kyung Hee University, Seoul, South Korea.

⁷Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.

⁸Department of Clinical Oncology, Queen Elizabeth Hospital, Hongkong SAR, China.

⁹Department of Urology, Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.

^* Address correspondence to: chocs@ha.org.hk (W.C.C.);

^* Address correspondence to: zhaojielv@pkuszh.com (Z.L.);

^* Address correspondence to: dechao.feng@ucl.ac.uk (D.F.)

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Received	Accepted	Published
2025-11-17	2026-01-11
Issue Date
2026-10-16

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