Research

Research ›› 2026, Vol. 9 ›› Issue (1) : 1106 - . DOI: 10.34133/research.1106

REVIEW ARTICLE

Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives

Shengwen Cheng ¹^,²^,³ ,
Lijun Yang ⁴ ,
Mingfei Dong ¹^,²^,³ ,
Xiaohong Luo ⁵ ,
Xinle Zhang ⁶ ,
Yu Zhai ¹^,²^,³ ,
Yi He ⁷ ,
Yuqiao Wang ¹^,²^,³ ,
Xiaole Peng ¹^,²^,³ ,
Xiaoxiong Li ¹^,²^,³ ,
Yichi Zhang ¹^,²^,³^,⁹ ,
Chen Zhao ¹^,²^,³^,^* ,
João F. Mano ⁸^,^* ,
Wei Huang ¹^,²^,³^,^* ,
Yiting Lei ¹^,²^,³^,⁹^,^*

Author information +

¹Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

²Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, Chongqing 400016, China.

³Orthopedic Research Laboratory of Chongqing Medical University, Chongqing 400016, China.

⁴Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

⁵Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China.

⁶Ophthalmology Medical Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Branch (Municipality Division) of National Clinical Research Centre for Ocular Diseases, Chongqing 400016, China.

⁷Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China.

⁸Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, Aveiro 3810-193, Portugal.

⁹Department of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong SAR 999077, China.

^* Address correspondence to: lecraz@sina.com (C.Z.);

^* Address correspondence to: jmano@ua.pt (J.F.M.);

^* Address correspondence to: huangw511@163.com (W.H.);

^* Address correspondence to: leiyit614@163.com (Y.L.)

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Received	Accepted	Published
2025-12-07	2026-01-01
Issue Date
2026-10-16

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