Research

Research ›› 2026, Vol. 9 ›› Issue (7) : 1362 - . DOI: 10.34133/research.1362

RESEARCH ARTICLE

Dual-Mechanism Aptamer–Drug Complex Overcomes Paclitaxel Resistance in Ovarian Cancer via Structural Constraint and Telomerase Inhibition

Yuan Ma ¹^,² ,
Zefeng Chen ²^,³ ,
Xinyang Shen ⁴ ,
Feng Ding ³ ,
Nan Liu ⁴ ,
Sifan Yu ²^,³ ,
Jia-Ke Xu ⁵ ,
Hu Li ⁶ ,
Aiping Lu ³ ,
Huarui Zhang ¹ ,
Chuanxin Zhong ³ ,
Yihao Zhang ¹ ,
Fangfei Li ³ ,
Dong-Hua Yang ⁷ ,
Tao Tang ⁸^,^* ,
Bao-Ting Zhang ¹^,^* ,
Ge Zhang ³^,^*

Author information +

¹School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.

²Increasepharm & Hong Kong Baptist University Joint Centre for Nucleic Acid Drug Discovery, Hong Kong 999077, China.

³Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.

⁴Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

⁵Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

⁶Department of Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

⁷New York College of Traditional Chinese Medicine, Mineola, NY 11501, USA.

⁸Department of Obstetrics & Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.

^* Address correspondence to: tangtao@cuhk.edu.hk (T.T.);

^* Address correspondence to: zhangbaoting@cuhk.edu.hk (B.-T.Z.);

^* Address correspondence to: zhangge@hkbu.edu.hk (G.Z.)

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Received	Accepted	Published
2026-01-05	2026-06-25
Issue Date
2026-10-16

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