Research

Research ›› 2026, Vol. 9 ›› Issue (8) : 1374 - . DOI: 10.34133/research.1374

RESEARCH ARTICLE

Human Organoids Reveal PTEN-Driven Mesendoderm Specification via Retinoic Acid Signaling Suppression

Wuming Wang ¹^,²^,³^,⁴^,⁵^,⁶ ,
Qiqi He ¹^,² ,
Hong Zhang ¹^,² ,
See-Wing Chan ¹^,² ,
Zhiqiang Xiong ¹^,² ,
Haite Tang ¹^,² ,
Yue Lv ⁷ ,
Xianwei Su ⁸ ,
Ya Guo ⁹ ,
Yong Fan ¹⁰ ,
Xingguo Liu ¹¹ ,
Xiuwu Bian ⁸ ,
Andrew M. Chan ¹ ,
Hongbin Liu ²^,¹²^,^* ,
Gang Lu ¹^,²^,³^,⁴^,⁵^,⁶^,⁸^,¹³^,¹⁴^,^* ,
Wai-Yee Chan ¹^,²^,³^,⁴^,⁵^,¹³^,¹⁴^,^*

Author information +

¹School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

²CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

³Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

⁴Kunming Institute of Zoology–The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, The Chinese University of Hong Kong, Hong Kong SAR, China.

⁵CUHK-GIBH CAS Joint Research Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

⁶Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Science Park, Shatin, New Territories, Hong Kong SAR, China.

⁷Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan 250012, Shandong, China.

⁸Chongqing-Hongkong Healthtech Hub, Jinfeng Laboratory, Chongqing, China.

⁹Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

¹⁰Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China.

¹¹Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical University, Guangzhou, China.

¹²State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 250012, China.

¹³Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, The Chinese University of Hong Kong, Hong Kong SAR, China.

¹⁴The Chinese University of Hong Kong - University of Southampton Joint Laboratory for Stem Cell and Regenerative Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

^* Address correspondence to: hongbin_sduivf@aliyun.com (H.L.);

^* Address correspondence to: lugang@cuhk.edu.hk (G.L.);

^* Address correspondence to: chanwy@cuhk.edu.hk (W.-Y.C.)

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Received	Accepted	Published
2026-02-11	2026-07-06
Issue Date
2026-10-16

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