Research

Research ›› 2026, Vol. 9 ›› Issue (7) : 1351 - . DOI: 10.34133/research.1351

RESEARCH ARTICLE

Piezo1 Impairs Endothelial Barrier and Drives Aortic Aneurysm and Dissection via STAT3-Dependent Activation of the CCL2–CCR2 Axis

Kehui Yang ¹^,²^,³^,⁴^,⁵ ,
Yang Liu ¹^,²^,³^,⁴^,⁵ ,
Xiaoran Huang ⁶ ,
Dehui Hou ¹^,²^,³^,⁴^,⁵ ,
Han Du ¹^,²^,³^,⁴^,⁵ ,
Jingwen Wang ¹^,²^,³^,⁴^,⁵ ,
Hongwei Yue ¹^,²^,³^,⁴^,⁵ ,
Yunyun Guo ¹^,²^,³^,⁴^,⁵ ,
Sumei Cui ¹^,²^,³^,⁴^,⁵ ,
Huidan Zhang ¹^,²^,³^,⁴^,⁵ ,
Yijun Sun ¹^,²^,³^,⁴^,⁵ ,
Xin Li ⁶^,^* ,
Jun Ren ⁷^,^* ,
Feng Xu ¹^,²^,³^,⁴^,⁵^,^* ,
Yuguo Chen ¹^,²^,³^,⁴^,⁵^,^*

Author information +

¹Department of Emergency Medicine, Qilu Hospital, Shandong University, Jinan, China.

²Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.

³Medical and Pharmaceutical Basic Research Innovation Center of Emergency and Critical Care Medicine, China’s Ministry of Education, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Qilu Hospital of Shandong University, Jinan, China.

⁴NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University, Jinan, China.

⁵State Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, China.

⁶Department of Emergency Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

⁷Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

^* Address correspondence to: sylixin@scut.edu.cn (X.L.);

^* Address correspondence to: ren.jun@zs-hospital.sh.cn (J.R.);

^* Address correspondence to: xufengsdu@126.com (F.X.);

^* Address correspondence to: chen919085@sdu.edu.cn (Y.C.)

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Received	Accepted	Published
2026-01-14	2026-06-16
Issue Date
2026-10-15

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