Research

Research ›› 2024, Vol. 7 ›› Issue (12) : 0548 . DOI: 10.34133/research.0548

Research Article

Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis

Lu-Xi Chen ¹^,²^,³^,⁴^,^† ,
Mei-Di Zhang ⁵^,^† ,
Hai-Feng Xu ¹^,²^,³ ,
Hai-Qin Ye ⁶ ,
Dian-Fu Chen ¹^,²^,³ ,
Pei-Shan Wang ¹^,²^,³^,⁴ ,
Zhi-Wei Bao ⁵ ,
Sheng-Mei Zou ¹^,²^,³ ,
Yong-Ting Lv ¹^,²^,³^,⁴ ,
Zhi-Ying Wu ¹^,²^,³^,⁴^,⁷^,^*^,^‡ ,
Hong-Fu Li ¹^,²^,³^,^*

Author information +

¹Department of Medical Genetics and Center for Rare Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

²Nanhu Brain-Computer Interface Institute, Hangzhou, China.

³ Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Hangzhou, Zhejiang, China.

⁴Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

⁵Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

⁶Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China.

⁷MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.

^* Address correspondence to: hongfuli@zju.edu.cn (H.-F.L.); zhiyingwu@zju.edu.cn (Z.-Y.W.)

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Received	Accepted	Published
2024-06-23	2024-11-19
Issue Date
2025-07-24

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