Research

Research ›› 2024, Vol. 7 ›› Issue (7) : 0413 . DOI: 10.34133/research.0413

Research Article

Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model

Qian Wang ¹^,²^,³^,^† ,
Xiaonan Liu ¹^,²^,³^,^† ,
Hejian Zhang ¹^,³^,⁴^,^† ,
Huanyu Chu ¹^,²^,^† ,
Chao Shi ⁵^,^† ,
Lei Zhang ¹^,⁶ ,
Jie Bai ¹^,³ ,
Pi Liu ¹^,³ ,
Jing Li ¹^,³^,⁷^,⁸ ,
Xiaoxi Zhu ¹^,²^,³ ,
Yuwan Liu ¹^,³ ,
Zhangxin Chen ⁵ ,
Rong Huang ¹^,³ ,
Hong Chang ¹^,³ ,
Tian Liu ¹^,³ ,
Zhenzhan Chang ⁵^,^* ,
Jian Cheng ¹^,³^,^* ,
Huifeng Jiang ¹^,³^,^*

Author information +

¹Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

² University of Chinese Academy of Sciences, Beijing 100049, China.

³ National Center of Technology Innovation for Synthetic Biology, Tianjin 300308, China.

⁴College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

⁵Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

⁶College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, Hubei 430023, China.

⁷State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

⁸College of Life Science, Nankai University, Tianjin 300071, China.

^* Address correspondence to: jiang_hf@tib.cas.cn (H.J.); cheng_j@tib.cas.cn (J.C.); changz@bjmu.edu.cn (Z.C.)

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Received	Accepted	Published
2024-03-25	2024-05-27
Issue Date
2025-07-24

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