Research

Research ›› 2024, Vol. 7 ›› Issue (3) : 0336 . DOI: 10.34133/research.0336

Research Article

Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization

Chao Yu ¹^,²^,³^,⁴ ,
Jing Zhao ⁵ ,
Feng Cheng ¹^,²^,³^,⁴ ,
Jiangjie Chen ¹^,²^,³^,⁴ ,
Jinyang Chen ¹^,²^,³^,⁴ ,
Haibin Xu ¹^,²^,³^,⁴ ,
Kesi Shi ¹^,²^,³^,⁴ ,
Kaishun Xia ¹^,²^,³^,⁴ ,
Siwen Ding ⁶ ,
Kanbin Wang ¹^,²^,³^,⁴ ,
Ronghao Wang ¹^,²^,³^,⁴ ,
Yazhou Chen ¹^,²^,³^,⁴ ,
Hao Li ¹^,²^,³^,⁴ ,
Qixin Chen ¹^,²^,³^,⁴ ,
Xiaohua Yu ¹^,²^,³^,⁴ ,
Fangwei Shao ⁷^,⁸^,^* ,
Chengzhen Liang ¹^,²^,³^,⁴^,^* ,
Fangcai Li ¹^,²^,³^,⁴^,^*

Author information +

¹Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, PR China.

²Orthopedics Research Institute of Zhejiang University, Zhejiang University, Hangzhou 310009, Zhejiang, PR China.

³ Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310009, Zhejiang, PR China.

⁴ Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou 310009, Zhejiang, PR China.

⁵Department of Chemistry, Zhejiang University, Hangzhou 310009, Zhejiang, PR China.

⁶ Westlake Street Community Health Service Center, Hangzhou 310009, Zhejiang, PR China.

⁷Zhejiang University-University of Illinois at Urbana-Champaign Institute, Zhejiang University, Haining 314400, Zhejiang, PR China.

⁸Biomedical and Health Translational Research Centre, Zhejiang University, Haining 314400, Zhejiang, PR China.

*Address correspondence to: lifangcai@zju.edu.cn (F.L.); liangchengzhen@zju.edu.cn (C.L.); fangweishao@intl.zju.edu.cn (F.S.)

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Received	Accepted	Published
2024-01-02	2024-02-17
Issue Date
2025-07-24

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