Research

Research ›› 2025, Vol. 8 ›› Issue (5) : 0717 . DOI: 10.34133/research.0717

Research Article

An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients

Yuan Cai ¹^,²^,³^,^*^,^† ,
Yonghao Gu ¹^,^*^,^† ,
Jie Zhang ²^,^† ,
Ying Zhu ² ,
Zhen Ma ² ,
Qin He ¹ ,
Yongjia Sun ¹ ,
Mengmeng Yuan ² ,
Xiaojun Li ¹ ,
Kai Zhu ¹ ,
Bolong Miao ² ,
Jin Zhao ² ,
Juan Liu ² ,
Min Tang ² ,
Dali Tong ¹ ,
Lixia Feng ⁴ ,
Ming Ma ¹^,^* ,
Guisheng Zhong ⁵^,⁶^,^* ,
Zilong Qiu ²^,⁷^,⁸^,^* ,
Tian Xue ¹^,³^,^*

Author information +

¹ First Affiliated Hospital of USTC, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.

² Starrygene Therapeutics Company Limited, Hefei 230031, China.

³ Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China.

⁴ The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.

⁵ iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

⁶ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

⁷ Songjiang Research Institute, Songjiang District Central Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

⁸ Clinic Neuroscience Center, Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

^* Address correspondence to: xuetian@ustc.edu.cn (T.X.); qiuzilong@shsmu.edu.cn (Z.Q.); zhongsh@shanghaitech.edu.cn (G.Z.); mm685@ustc.edu.cn (M.M.); guyh@ustc.edu.cn (Y.G.); cy0901@ustc.edu.cn (Y.C.)

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Received	Accepted	Published
2024-12-09	2025-05-04
Issue Date
2025-07-23

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