Research

Research ›› 2025, Vol. 8 ›› Issue (1) : 0599 . DOI: 10.34133/research.0599

Research Article

Discovery of Novel Na_v1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief

Gaoang Wang ¹^,^† ,
Hang Wu ²^,^† ,
Yingying Wang ³^,^† ,
Xiangying Liu ⁴ ,
Shuijiao Peng ² ,
Wenxing Wang ² ,
Meijing Wu ² ,
Yifei Liu ¹ ,
Ercheng Wang ⁵ ,
Zhe Wang ⁶ ,
Lei Xu ⁷ ,
Xiaojian Wang ⁴^,^* ,
Wei Yang ³^,^* ,
Haiyi Chen ¹^,^* ,
Xi Zhou ²^,^* ,
Tingjun Hou ¹^,^*

Author information +

¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.

² The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, and Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha 410081, Hunan, China.

³ Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.

⁴ State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

⁵ Zhejiang Laboratory, Hangzhou 311100, Zhejiang, China.

⁶ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.

⁷ Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, Jiangsu, China.

^* Address correspondence to: tingjunhou@zju.edu.cn (T.H.); xizh@hunnu.edu.cn (X.Z.); 11619007@zju.edu.cn (H.C.); yangwei@zju.edu.cn (W.Y.); wangxiaojian@imm.ac.cn (X.W.)

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Received	Accepted	Published
2024-11-19	2025-01-09
Issue Date
2025-07-23

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