Research

Research ›› 2025, Vol. 8 ›› Issue (1) : 0545 . DOI: 10.34133/research.0545

Research Article

Protein Phosphatase 2A Promotes CD8⁺ T Cell Effector Function through the Augmentation of CD28 Costimulation

Kaixiang Zhu ¹^,²^,³^,^*^,^† ,
Deepak Rohila ⁴^,⁵^,^† ,
Yuanling Zhao ⁴^,^† ,
Dmytro Shytikov ⁶ ,
Lize Wu ⁴ ,
Fan Zhao ⁴ ,
Shurong Hu ⁷ ,
Qin Xu ⁸ ,
Xuexiao Jin ⁴^,^* ,
Linrong Lu ¹^,⁴^,⁹^,^*

Author information +

¹ Department of Cardiology of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

² State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China.

³ Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou 310009, China.

⁴ Institute of Immunology, and Department of Rheumatology in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

⁵ Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.

⁶ Zhejiang University–University of Edinburgh Institute, Zhejiang University School of Medicine, 314400 Haining, China.

⁷ Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

⁸ Cell Signaling and Immunity Section, Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

⁹ Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai 200025, China.

^* Address correspondence to: lu_linrong@zju.edu.cn (L.L.); zhu_kaixiang@zju.edu.cn (K.Z.); shirleyj@zju.edu.cn (X.J.)

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Received	Accepted	Published
2024-07-06	2024-11-14
Issue Date
2025-07-23

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